ESS - DM - Análises Clínicas e Saúde Pública
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Browsing ESS - DM - Análises Clínicas e Saúde Pública by Subject "Aging"
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- Cellular senescense: an overview on characteristics, effects and senotherapyPublication . Ferreira, Patrícia dos Santos; Castro, José Pedro; Sousa, Maria Manuela Amorim de Silva e; Lamas, Maria Céu RibeiroCellular senescence is defined as part of the aging process that can be found throughout the life cycle and, i tis linked to age-related chronic pathologies like diabetes, Alzheimer’s, Osteoporosis, Cancer and many others. For several years, cellular senescence has been portrayed as detrimental, shadowing any potential benefits of senescence. It is of extreme importance to understand what changes happen in the cells during senescence. It is of extreme importance to understand what changes happen in the cells during senescence and grasp their role in aging to fully understand its role in adaptation and damage features. The goal of this study was to conduct a review of the state of the art in cellular senescence, types, main charateristics and its role in health and disease. Using the PRISMA methodology, a query with specified keywords was used. Fourteen studies were analyzed. It is importante to highlight that the use of fibroblasts as a suitable model to develop studies, the role of BAFF signaling as a future reference in senotherapy studies and probe XZ1208 as a new method of identification of senescente cells.
- Prenatal inflammation dysregulation and susceptibility to diseases: a systematic review on the first step of accelerated agingPublication . Pinho, Catarina Vaz; Castro, José Pedro; Sousa, Maria Manuela Amorim de Silva e; Lamas, Maria Céu RibeiroWith increasing life expectancy, it came higher incidence of chronic illnesses. Throughout life, low chronic inflammation accumulates, causing detrimental effects that accelerates aging. To identify where is this inflammation begins, this review focused on inflammation befor birth, searching for a relation between inflammation deviation during pregnancy and the development od chronic diseases. The search was conducted in April 2024 in PubMed, Embase and Web of Science databases, using similar queries. All the data was handled in Microsoft Excell and PRISMA guidelines were implemented. A total of 20 articles were included for analyze, mostly experimental stidies. The most emphasized biomarkers were IL-6, IL.1β e TNF-α, nd the most referenced were associated with brain and pulmonar fetal development, in relation to preterm birth. There is a clear influence of cytokines unbalance in the health of the fetus and future chronic diseases development. It would be important to develop strategies to follow pregnancies throughout this final trimester to intervene and allow full development or measure inflammation to prevent future generations from this reality.