REPOSITÓRIO P.PORTO
Repositório Científico do Politécnico do Porto
Entradas recentes
Towards a multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating evidence from a critical review into a model for future research
Publication . Pinto, Joana O.; Peixoto, Bruno; Dores, Artemisa R.; Barbosa, Fernando; Dores, Artemisa
The main purpose of this work is to critically review the literature on neurocognitive disorders (ND) diagnosis. A critical review was conducted in PubMed, Scopus, and EBSCO. Systematic reviews and meta-analyses focusing on ND diagnosis were included. The selected studies were critically analyzed and conceptually integrated to identify relevant dimensions for the diagnosis of ND. The review included 88 studies. Most studies focused on Alzheimer’s disease and mild cognitive impairment. The literature remained predominantly centred on isolated diagnostic domains, and important limitations were consistently identified, including methodological heterogeneity, lack of standardized thresholds, and reduced clinical applicability. Based on the identified conceptual and methodological limitations, a Multidimensional Model of Neurocognitive Disorders (MOND model) for ND diagnosis was proposed. The MOND model was developed as a multidimensional, multilevel, transdiagnostic model integrating biological, neurocognitive, neuropsychiatric, motor, functional, frailty, reserve-related, and socio-environmental dimensions. The model may contribute to research, symptom classification, severity characterization, prognosis, and personalized intervention planning across different ND trajectories. Future studies using the MOND model should focus on refining algorithms to estimate the risk of ND.
Impact of shoulder pain on upper limb function: An observational study in post-stroke individuals
Publication . Lopes, Sofia; Fernandes, Ângela; Lopes, Sofia; Fernandes, Ângela
Shoulder pain is a frequent complication after stroke, often associated with reduced arm function, decreased independence, and poorer quality of life. This study aimed to investigate the relationship between post-stroke shoulder pain, motor performance, functional outcomes, and spasticity to provide clinically relevant evidence for rehabilitation. We conducted an observational study including individuals who had experienced a stroke and were undergoing neurorehabilitation. Pain severity and its interference with daily activities were measured through structured clinical evaluation. Motor outcomes were assessed with standardized functional and strength tests, and spasticity was measured using a validated clinical scale. Sociodemographic and clinical variables, including time since stroke and stroke type, were also collected. The mean pain severity score was 4.82 (standard deviation 1.72). Pain severity correlated strongly with pain interference, although neither was significantly associated with motor or functional performance. Motor and functional variables were interrelated: motor recovery scores correlated positively with functional independence and grip strength, and negatively with spasticity. Time since stroke influenced outcomes, with poorer motor and functional results in participants more than two years post-event. Stroke type influenced pain, with greater interference reported in patients with ischemic stroke. No significant differences were observed between sexes. These findings highlight the multifactorial nature of shoulder pain after stroke and emphasize the importance of early and individualized rehabilitation strategies. Addressing pain, spasticity, and functional limitations together may improve long-term outcomes and quality of life for individuals living with the consequences of stroke.
Espondilite Anquilosante: Alterações nos perfis lipídico e inflamatório
Publication . Valério, Nádia; Amorim, Maria Manuela; Ferreira, Stéphanie Lopes; Mota, Sandra Marlene; Moreira, Teresa; Moreira, Anabela; Mota, Sandra; Amorim Sousa, Maria Manuela; Lopes Ferreira, Stephanie
A Espondilite Anquilosante (EA) é uma doença inflamatória crónica que acomete principalmente as articulações sacroilíacas, com consequente limitação da mobilidade. Vários estudos observaram que os doentes com EA apresentam alterações séricas do perfil lipídico, nomeadamente um aumento dos níveis de lipoproteínas de baixa densidade (LDL) e uma diminuição de lipoproteínas de alta densidade (HDL), em relação à população geral. Adicionalmente, como a EA é uma doença imunológica associada a um carácter inflamatório, os doentes com EA apresentam, geralmente, um perfil inflamatório alterado. Os perfis lipídico e inflamatório aterogénicos podem traduzirse num risco aumentado de doenças cardiovasculares (DCV).
Alteração do perfil lipídico em pacientes com esquizofrenia
Publication . Oliveira, Paula; Sousa, Maria; Ferreira, Stéphanie; Moreira, Anabela; Lopes Ferreira, Stephanie; Amorim Sousa, Maria Manuela
A esquizofrenia (SCZ) é uma patologia que envolve uma série de disfunções fisiológicas, cognitivas e emocionais. A terapêutica farmacológica evoluiu nas últimas décadas, sendo prescritos atualmente a estes pacientes antipsicóticos que têm permitido a sua melhor integração na comunidade. No entanto, os antipsicóticos apresentam efeitos colaterais, como alterações no metabolismo da glicose e dos lípidos que, por sua vez, aumentam o risco de síndrome metabólica (SM) e de doenças cardiovasculares nestes pacientes.
Caracterização do perfil hematológico de uma população envelhecida em função da sua atividade física e estado nutricional
Publication . Moreira, Anabela; Louro, Rafael; Ferreira, Stéphanie; Mota, Sandra; Amorim, Manuela; Lopes Ferreira, Stephanie; Amorim Sousa, Maria Manuela
Nos países desenvolvidos tem-se verificado um acentuado envelhecimento populacional. O processo de envelhecimento implica alterações ao nível da constituição corporal, sendo frequentes alterações no estado nutricional, na capacidade física e motora, refletidas na maior incidência e progressão de patologias nesta população. Assim, é importante identificar fatores modificáveis que permitam melhorar ou manter a qualidade de vida desta população. O estado de saúde do indivíduo pode ser avaliado através de indicadores analíticos, incluindo o hemograma.