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- Avaliação dos resultados da aplicação combinada do ultrassom e da drenagem linfática manual no fibro-edema gelóidePublication . Rodrigues, Elisa; Lopes, André; Adubeiro, Nuno; Faria, MiriamO fibro-edema gelóide (FEG), popularmente conhecido como celulite, é uma alteração comum da topografia da pele que reflete disfunções precoces nos sistemas vascular e/ou metabólico e conjuntivo, afetando milhões de pessoas no mundo, predominantemente mulheres. A partir de perspetivas em saúde cada vez mais holísticas e integrativas, poder-se-á usar o FEG como indicador precoce para doenças cardiovasculares e metabólicas. As terapias eficazes podem ser chaves no diagnóstico dos principais sistemas disfuncionantes envolvidos. Muitos métodos são utilizados no seu tratamento, entre os quais se incluem a drenagem linfática manual (DLM) e o ultrassom.
- Bone mineral density in vocational and professional ballet dancersPublication . Amorim, T.; Koutedakis, Y.; Nevill, A.; Wyon, M.; Maia, J.; Machado, J. C.; Marques, F.; Metsios, G.S.; Flouris, A.D.; Adubeiro, Nuno; Nogueira, L.; Dimitriou, L.According to existing literature, bone health in ballet dancers is controversial. We have verified that, compared to controls, young female and male vocational ballet dancers have lower bone mineral density (BMD) at both impact and non-impact sites, whereas female professional ballet dancers have lower BMD only at non-impact sites.
- Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to differentiate normal from malignant tissuePublication . Adubeiro, Nuno; Nogueira, Maria Luísa; Nunes, Rita G.; Ferreira, Hugo Alexandre; Ribeiro, Eduardo; La Fuente, José Maria FerreiraPurpose Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues. Methods Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500 s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC) > 95%. Results 15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000 s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89 × 10–3 mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%. Conclusions The best b-value pair was b = 50, 2000 s/mm2.
- Endocrine parameters in association with bone mineral accrual in young female vocational ballet dancersPublication . Amorim, Tânia; Metsios, George S.; Flouris, Andreas D.; Nevill, Alan; Gomes, Thayse N.; Wyon, Matthew; Marques, Franklim; Nogueira, Luisa; Adubeiro, Nuno; Jamurtas, Athanasios Z.; Maia, José; Koutedakis, YiannisLess is known on bone mass gains in dancers involved in vocational dance training. The present study found that, as young vocational dancers progress on their professional training, their bone health remains consistently lower compared to non- exercising controls. Endocrine mechanisms do not seem to explain these findings.
- Diffusion MRI outside the brainPublication . Nunes, Rita G.; Nogueira, Luisa; Gaspar, Andreia S.; Adubeiro, Nuno; Brandão, SofiaThis manuscript provides an overview of recent developments in Diffusion-Weighted Imaging (DWI) outside the brain, focusing on liver, breast, prostate, muskuloskeletal (MSK) and cardiac applications. A general introduction to cross-cutting acquisition and image processing challenges is first provided. These often include short T2 relaxation times, the need to image a large field-of-view with the resulting complications in shimming the B0 field and achieving good fat suppression. Some of the strategies developed for dealing with motion, namely cardiac and respiratory motion are described. Specific sections are then presented for each of the aforementioned organs. A motivation for the clinical applicability of DWI is first provided, followed by specific image acquisition and processing considerations. Quantitative imaging is becoming standard in clinical practice, and the Apparent Diffusion Coefficient is routinely estimated in the liver, breast and prostate. Application of alternative signal models in these organs is being explored, including both the Intravoxel Incoherent Motion and Diffusion Kurtosis models. Ongoing efforts are focused on evaluating the potential clinical added value of the extra parameters and on improving their repeatability. MSK and cardiac DWI have shown potential for assessing pathological changes in fiber architecture, but further validation is required to enable application in the clinical setting.
- Editorial for “Three‐dimensional multifrequency MR elastography for microvascular invasion and prognosis assessment in Hepatocellular Carcinoma”Publication . Adubeiro, Nuno; Nunes, Rita G.; Nogueira, LuísaThe prognosis of individuals with hepatocellular carcinoma(HCC), the most prevalent primary liver malignancy, is closely linked to the aggressiveness and recurrence of the tumor. The occurrence of complications after surgery continues to be a major and persistent challenge. MR elastography (MRE) employs a modified phase-contrast imaging sequence, combined with the use of an external driver to transmit mechanical vibrations to the tissues, to identify propagating shear waves within the liver. This technique allows the assessment of a substantial portion of the liver and provides information on multiple mechanical properties associated with various pathophysiological states. Due to substantial progress in MR technology, MRE has proven to be a precise noninvasive diagnostic method for detecting and monitoring various liver diseases. MRE imaging could serve as a valuable tool for staging malignancy and predict disease prognosis.
- Influence of the minimum b-value on prostate cancer assessment using conventional DWI and DKI modelsPublication . Adubeiro, N.; Nogueira, L.; Nunes, R. G.; Ferreira, H. A.; Ribeiro, E. F. C.; Fuente, J. M. LaTo investigate the influence of the minimum b-value in diffusion parameters estimated for prostate tissues using mono-exponential and kurtosis models.
- Dual source/dual energy-renal applicationsPublication . Adubeiro, Nuno; Nogueira, Luísa; Guedes, Mónica; Pinho, ErnestoDevelopment of Dual Source Computed Tomography (Definition, Siemens Medical Solutions, Erlanger, Germany) allowed advances in temporal resolution, with the addition of a second X-ray source and an array of detectors to the TCM 64 slices. The ability to run exams on Dual Energy, allows greater differentiation of tissues, showing differences between closer attenuation coefficients. In terms of renal applications, the distinction of kidney stones and masses become one of the main advantages of the use of dual-energy technology. This article pretends to demonstrate operating principles of this equipment, as its main renal applications.
- Imaging for radiofrequency ablationPublication . Adubeiro, Nuno; Pereira, Daniel; Nogueira, Luísa; Pinho, ErnestoMany solid tumors have a poor response to systemic chemotherapy, local radiotherapy or surgical recession. They are responsible for premature morbidity and decreased patient survival. The radiofrequency ablation is an emerging technique, and is now becoming more widespread throughout the world because it is minimally invasive, image guided, which offers the possibility of an effective and less costly approach. The procedure can be performed percutaneously, guided by several imaging modalities as Ultrasound, Computed Tomography and Magnetic Resonance. This article pretends to demonstrate the state-of-the-art of this technique focusing in the technical aspects and application of radiofrequency ablation.
- Investigação clínica – Aspectos globaisPublication . Adubeiro, NunoO campo da investigação na saúde é inerentemente uma área de extrema compexidade, com muitas particularidades, mas cujo aporte é fulcral pra que se possam tomar decisões baseadas na evidência.
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