ESS - GAS - Comunicações em eventos científicos
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- Key principles involving ethical and deontological issues in military stress management training in virtual reality environmentsPublication . Gomes, Paulo Veloso; Vianez, Ana; Curado, Henrique; Marques, António; Pereira, Javier; Machado Veloso Gomes, Paulo Sérgio; Pereira da Silva Marques, António José; Curado, HenriqueThe integration of Virtual Reality in military contexts, which simulates realistic combat and high-risk operational scenarios, provides a controlled environment for developing various skills and psychological resilience. This technology has proven to be a valuable tool for enhancing soldiers’ training and preparedness. The creation and use of VR programs, especially those involving the collection of biofeedback data to study military stress, carry significant ethical and deontological responsibilities. This study examines the regulation of using powerful algorithms to analyse biofeedback data to study military stress, emphasizing informed consent, privacy and confidentiality, beneficence and nonmaleficence, transparency in data usage and compliance with legal and regulatory standards.
- Phagetherapies for infections caused by P. aeruginosaPublication . Ferraz, Ricardo; Reis, Ana; Prudêncio, Cristina; Baylina, Pilar; Fernandes, Rúben; Ferraz, Ricardo; Prudêncio, Cristina; BAYLINA MACHADO, PILAR; Fernandes, RúbenThe hospital infections can be prevented by controlling some factors related with staff, material, and environment. At this moment the existing legislation regulates procedures that prevent the propagation of the infection and/or of the agents that causes it. The Pseudomonas aeruginosa is a gram-negative opportunistic responsible for most of the hospital infections. Because it is opportunistic it is more frequent in immunocompromised patients submitted to transplants and surgical interventions. In short, this thesis has contributed for the understanding of the biology of P. aeruginosa , antibacterial treatment and its resistance to this treatment by using efflux bombs, and so as establishing associations with others factors, such as biochemical. This study has the objective to understand the resistance factors used by the P. aeruginosa in order to develop alternative therapies for this agent. Initially, 72 hospitalar isolated were characterized and 91.67% have revealed more than 3 classes of Antimicrobians.
- Fatores psicossociais de risco nos psicólogos: qual o impacto no bem-estar social?Publication . Barros, C.; Fonte, C.; Alves, S.; Baylina, PilarA prática da psicologia pode ser muito desgastante e emocionalmente exaustiva, o que a torna suscetível a riscos ocupacionais, nomeadamente, riscos psicossociais. O objetivo deste estudo foi avaliar os fatores psicossociais de risco e explorar os preditores de saúde mental e bem-estar, nomeadamente o bem-estar social. 339 psicólogos participaram do estudo e os resultados identificaram elevado ritmo e intensidade de trabalho, falta de autonomia e iniciativa, níveis altos de exigência emocional e alguns fatores significativos, ao nível das relações de trabalho. Foram identificados preditores de bem-estar social, mais concretamente: Estar sempre a mudar de função e de tarefas (β = -1,810), e Não poder participar nas decisões (β = 2,470). É importante desenvolver melhores práticas organizacionais para promover a saúde mental e o bem-estar social.
- Existe relação entre a infeção por SARS-COV-2 e diabetes MELLITUS em Portugal?Publication . Correia, C.; Fernandes, Rúben; Baylina, Pilar; Faria, B.Em 2019 assistiu-se ao aparecimento da doença causada pelo SARS-CoV-2 que é conhecida como COVID-19, na China. A pandemia do COVID-19 foi declarada em 2020, pela OMS e ainda hoje assola todo o mundo. A COVID-19 é altamente infeciosa e a maioria dos pacientes tem mais de 50 anos, sendo que estes apresentam pelo menos uma comorbilidade associada, entre as quais a Diabetes mellitus (Dm). A Dm é uma doença metabólica em que se verificam níveis elevados de glicose no sangue, durante um longo período. Neste trabalho pretende realizar um estudo bioestatístico da relação entre infeção por SARS-CoV-2 e Dm em Portugal. Neste estudo foram utilizados os dados estatísticos disponibilizados pela Direção Geral de Saúde, Ministério da Saúde, Instituto Nacional de Estatística e PORDATA, relativamente a 2020. O estudo bioestatístico e respetivas análises foram realizadas utilizando o software IBM SPSS Statistics. Os dados foram testados para verificar a sua normalidade usando teste de Shapiro-Wilk. Dado não se verificar a normalidade, calculou-se a correlação de Spearman. A correlação entre as variáveis foi investigada nas diferentes regiões. A correlação entre as variáveis total de casos e diabéticos, o valor p é de <0.001 o que indica que o coeficiente de correlação de 0.964 é estatisticamente significativo. O coeficiente de correlação positivo indica que quando a proporção de população com Diabetes aumenta, a proporção de população com COVID-19 também aumenta. Este estudo explorou a correlação entre COVID-19 e Dm e usando todos os dados disponíveis até 31 de dezembro de 2020, para Portugal. Os resultados deste trabalho mostram um coeficiente de correlação positivo bastante significativo entre as duas doenças (COVID-19 e Dm). Isto indica que se a prevalência de Dm aumenta, a prevalência de casos COVID-19 também aumenta.
- The synergic effect of antibiotics is dependent of oxidative stress genes in Pseudomonas aeruginosaPublication . Fernandes, Rúben; Coelho, Pedro Barata; Guedes, Carla; Gojon, Frantz; Oliveira, Marco; Veiga, Marlene; Sá, Sara; Silva, Carina; Baylina, PilarPseudomonas aeruginosa is a Gram-negative opportunistic pathogen commonly found in Cystic fibrosis, infected wound of the diabetic foot among others. Clinical management of such infection depends deeply on the antibiotic therapy. Antibiotic response is dependent, among several other factors, to the response to host stress conditions, such as low-grade inflammation, metabolic conditions and oxidative stress and to social bacteria response such as quorum sensing and biofilm formation. P. aeruginosa, in particular strain PAO1 is also a biological model for studying bacterial biofilm formation. The present study aims to understand the antibiotic synergic response (ampicillin, ceftazidime, ciprofloxacin) in biofilm formation / degradation of 10 PAO1 oxidative gene mutants. Viability was measured by means of Erythrosin B and biofilm formation was measured by Crystal Violet assay. PAO1 GRLX, SEPHS 1, Rub A1, where the strains with a most pronounced biofilm formation and combination of ceftazidme::ciprofloxacin were most efficient in this biological model. The results are interesting, and although they are encouraging, they should be taken with caution.
- Oxidative stress genes involved in the virulence-dependent susceptibility to antibiotics in Pseudomonas aeruginosaPublication . Coelho, Pedro Barata; Fernandes, Ruben; Silva, Carina; Oliveira, Marco; Veiga, Marlene; Sá, Sara; Vieira, André; Guedes, Carla; Baylina, PilarPseudomonas aeruginosa is a Gram-negative opportunistic pathogen which rarely causes disease in healthy people. P. aeruginosa, in particular strain PAO1 is also a biological model for studying virulence and bacterial social traits, such as quorum sensing, SOS response among other. Antibiotic response is dependent, among several other factors, to the response to environmental stress conditions. The present study aims to understand the role of 10 PAO1 oxidative gene mutants in the response to antibiotic stress in elastase, protease and pyocyanin-dependent virulence factors. PAO1 was stressed to several antibiotics (penicilins, cephalosporins, macrolides, and quinolones), and the virulence proteins were measured by means of spectroscopic methods. Viability was measured by means of Erythrosin B. PAO1 GGT, GLO1, RubA2, GSH A mutants were the most susceptible to the production of virulence-dependent factors.
- Phylogenetic Insights of β-lactam resistance of the CTX-M familyPublication . Coelho, Pedro Barata; Mendonça, Jacinta; Silva, Carina; Baylina, Pilar; Fernandes, Ruben; Guedes, CarlaBacterial resistance is a major public health concern, particularly against β-lactam antibiotics, one of the most widely used antibacterial drugs. The production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of diffusion in different epidemiological contexts, outnumbering the others. Originated in chromosomal genes of Klyvera spp., the blaCTX-M genes have become associated with mobile genetic elements, such as plasmids, that have mediated inter-replication and dissemination. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants belonging to several sub-lineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular and structural point of view through homology in amino acid sequences. There are currently 6 defined clusters (CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25 and CTX-M-151), with the domains CTX -M-1 and CTX-M-9 presenting subgroups, composed mainly of variants identified as hybrids between them (particularly between CTX-M-14 and CTX-M-15).
- Strategy for data cybersecurity in european health data ecosystemPublication . Curado, Henrique; Gomes, Paulo Veloso; Jacquinet, Marc; Marques, António; Pereira, JavierThis study aims to analyze the Strategy for Data Cybersecurity in the European Health Data Ecosystem, to be implemented in 2025. The document analysis was carried out to map the different proposals for a regulation of the European Parliament and of the Council, regarding the sharing of the Electronic Health Record in the European space, and the General Data Protection Regulation implemented in the European Union. After an exhaustive documentary analysis, inconsistencies or flaws were detected that could compromise the rights of citizens enshrined in the General Data Protection Regulation.
- Perceções de estudantes da área da saúde póspandemia: estudo observacionalPublication . Cruz, Agostinho; Machado, Alberto; Cabral, Ana Paula; Tavares, Diana; Sousa, Helena; Curado, Henrique; Faria, Isabel; Sousa, Maria; Gonçalves, Maria João; Lopes, Paula; Monteiro, PedroO contexto pandémico vivenciado por toda a comunidade portuguesa nestes últimos meses, constituiu indubitavelmente um ambiente e um conjunto de experiências totalmente novas e singulares para todos os cidadãos, mas sobretudo para os jovens adultos. A pandemia e o confinamento, trouxe restrições no acesso a simulações práticas e especializadas assim como a locais de ensino clínico em contexto real e presencial, fundamental para a aquisição de competências clínicas e integração de realidades organizacionais de serviços cuidados de saúde. Neste contexto ao nível da área da saúde os desafios foram ímpares e alteraram a dinâmica profissional e as interações sociais.
- The relevance of an ethics committee in a higher education institution in the health area: The experience of ESS-P.PORTOPublication . Monteiro, Pedro; Tavares, Diana; Cruz, Agostinho; Cabral, Ana Paula; Machado, Alberto; Curado, Henrique; Sousa, Helena; Faria, Isabel; Gonçalves, Maria João; Sousa, Maria; Marques, António; Lopes, Paula; Prudêncio, CristinaEthics Committees arose as consequence of medical-scientific advances made in an eminent demand to extend morality and ethics to the field of biomedicine, to expand and preserve autonomy and dignity of human beings. The Ethics Committee (EC) of Escola Superior de Saúde (ESS) was born in February 2011. The importance for this unit of P.PORTO in having such a committee, for ethical and not legal imperative, came to be corroborated by law (Decree-Law no. 80/2018).