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Browsing ESS - CSH - Artigos by Author "Almeida, Isabel"
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- An fMRI paradigm based on Williams inhibition test to study the neural substrates of attention and inhibitory controlPublication . Dores, Artemisa Rocha; Barbosa, Fernando; Carvalho, Irene P.; Almeida, Isabel; Guerreiro, Sandra; da Rocha, Benedita Martins; Cunha, Gil; Castelo Branco, Miguel; de Sousa, Liliana; Castro Caldas, AlexandreThe purpose of this study is to present an fMRI paradigm, based on the Williams inhibition test (WIT), to study attentional and inhibitory control and their neuroanatomical substrates. We present an index of the validity of the proposed paradigm and test whether the experimental task discriminates the behavioral performances of healthy participants from those of individuals with acquired brain injury. Stroop and Simon tests present similarities with WIT, but this latter is more demanding. We analyze the BOLD signal in 10 healthy participants performing the WIT. The dorsolateral prefrontal cortex, the inferior prefrontal cortex, the anterior cingulate cortex, and the posterior cingulate cortex were defined for specified region of interest analysis. We additionally compare behavioral data (hits, errors, reaction times) of the healthy participants with those of eight acquired brain injury patients. Data were analyzed with GLM-based random effects and Mann-Whitney tests. Results show the involvement of the defined regions and indicate that the WIT is sensitive to brain lesions. This WIT-based block design paradigm can be used as a research methodology for behavioral and neuroimaging studies of the attentional and inhibitory components of executive functions.
- Impacto de um programa holístico de reabilitação neuropsicológica na qualidade de vida de pessoas com lesão cerebral adquiridaPublication . Almeida, Isabel; Guerreiro, Sandra; Martins-Rocha, Benedita; Dores, Artemisa Rocha; Vicente, Selene G.; Barbosa, Fernando; Castro-Caldas, AlexandreA reabilitação após lesão cerebral adquirida (LCA) pretende aumentar a funcionalidade do indivíduo, promovendo a sua Qualidade de Vida (QdV). O objetivo deste estudo é avaliar o impacto de um programa holístico de reabilitação neuropsicológica (PHRN) nas dimensões da QdV. Participaram 20 pessoas com LCA, média de idades 30 anos (DP = 7.62). Os participantes foram avaliados pré e pós intervenção, com intervalo de seis meses, utilizando-se o Quality of Life After Brain Injury (QOLIBRI). Para a análise usamos o t-testpara amostras emparelhadas, com p corrigido para comparações múltiplas. Verificam-se resultados significativos após a intervenção em todas as dimensões: total [t(19) = -4.59, p < .001], cognitiva [t(19) = -2.31, p = .003], self[t(19) =-5.76, p < .001],AVD (atividades de vida diária)[t(19) = -3.18, p = .001], social[t(19) = -1.29, p = .001], emocional [t(19) = -1.85, p = .001], com exceção da dimensão físico [t(19) = -1.78, p = .01]. Os resultados sugerem que a intervenção com o PHRN promove a QdV das pessoas com LCA.
- Impacto de um programa holístico de reabilitação neuropsicológica na qualidade de vida de pessoas com lesão cerebral adquiridaPublication . Almeida, Isabel; Guerreiro, Sandra; Martins-Rocha, Benedita; Dores, Artemisa Rocha; Vicente, Seline G.; Barbosa, Fernando; Castro-Caldas, AlexandreAfter acquired brain injury (ABI) rehabilitation aims to increase the individual’s functio-nality promoting their Quality of Life (QoL). The main goal of this study was to evaluate the impact of a holistic neuropsychological rehabilitation program (HNRP) on quality of life dimensions. Twenty subjects with ABI participated, mean age 30 years (SD=7.62). Participants were assessed pre and post intervention, with a six months interval, using Quality of Life After Brain Injury (QOLIBRI) A paired-sample t-test was conducted for data analyzes, with corrected p for multiple comparisons. Significant results after inter-vention were observed at all dimensions: total [t(19) = -4.59, p < .001], cognitive [t(19) = -2.31, p = .003], self[t(19) =-5.76, p < .001],DLAs(daily life activities)[t(19) = -3.18, p = .001], social[t(19) = -1.29, p = .001], emotional [t(19) = -1.85, p = .001], except on physical [t(19) = -1.78, p = .01]. Results suggest that intervention, after ABI, with the HNRP improves patients’ QoL.
- Influence of clinical and psychosocial factors on the adherence to topical treatment in psoriasisPublication . Teixeira, Ana; Teixeira, Maribel; Gaio, Rita; Torres, Tiago; Magina, Sofia; Dinis, Maria Alzira Pimenta; Sousa-Lobo, José; Almeida, Isabel; Peixoto, Miguel; Almeida, VeraPsoriasis is a common chronic inflammatory skin disease with different manifestations, affecting the quality of life at social, emotional, and professional dimensions and requiring long-term treatment. This study aimed to investigate the effect of psychosocial and clinical factors on adherence to topical treatment in psoriasis. Self-reported measures and weighing the medicines were used to assess adherence. Psychopathological symptoms were measured using the Brief Symptoms Inventory (BSI). Social and clinical factors were assessed by a sociodemographic and clinical questionnaire. Adherence to treatment with topical medication was assessed using a sample of 102 psoriasis patients. The explanatory models of adherence to topical treatment in psoriasis translated into positive associations between adherence and the education level (higher education) (p = 0.03; φ = 0.23), the single-family household (p = 0.01; φ = 0.44), active employment status (p = 0.05; φ = −0.19), familiar history of psoriasis (p = 0.04; φ = −0.21), and the presence of obsessive-compulsive symptoms (p = 0.01; d = 0.29). (4) Conclusions: In patients who present the characteristics identified that influence non-adherence, instructions should be reinforced to increase adherence. The experimental mortality (39.6%) reduced the sample size, representing a limitation of the study.