Publicação
Sensing the mind: label-free miRNA-based sensor as a diagnostic tool for neurodevelopmental disorders
| dc.contributor.author | Pereira, Eduarda | |
| dc.contributor.author | Santos, Renata | |
| dc.contributor.author | Prior, Catarina | |
| dc.contributor.author | Santos, Marlene | |
| dc.contributor.author | Teixeira, Ana Luísa | |
| dc.contributor.author | Barroso, M. Fátima | |
| dc.contributor.author | Santos, Marlene | |
| dc.contributor.author | Almeida Rufo Pereira, Eduarda | |
| dc.date.accessioned | 2026-07-28T09:15:10Z | |
| dc.date.available | 2026-07-28T09:15:10Z | |
| dc.date.issued | 2026-05-29 | |
| dc.description.abstract | Mental health disorders, including Attention-Defi-cit/Hyperactivity Disorder (ADHD) and autism spec-trum disorder (ASD), are global public health concerns that lack accurate and fast diagnostic tools. Recent evidence highlights miR-151a-3p as a promising circu-lating biomarker, as its levels in plasma and saliva are associated with neurodevelopmental disorders. How-ever, current detection methods like RT-qPCR are ex-pensive and time-consuming, which creates a demand for innovative point-of-care solutions. Highly sensitive electrochemical biosensor for the direct detection of miR-151a-3p emerge as promising alternatives, in gold screen-printed electrodes functionalized with a specific DNA-151a-3p capture probe. The biosensor’s assembly and the hybridization events were moni-tored using cyclic voltammetry (CV) and electrochem-ical impedance spectroscopy (EIS). Preliminary results indicate that the biosensor exhibits high selectivity and sensitivity, distinguishing the target miR-151a-3p from non-complementary sequences within biologi-cally relevant concentration ranges. This label-free ap-proach offers a significant advantage over traditional assays by providing a cost-effective, fast, and portable diagnostic tool. | eng |
| dc.description.sponsorship | COMPETE2030-FEDER-00699000 | |
| dc.identifier.citation | Pereira, E., Santos, R., Prior, C., Santos Moreira, M., Teixeira, A. L., & Barroso, M. F. (2026). Sensing the mind: Label-free miRNA-based sensor as a diagnostic tool for neurodevelopmental disorders. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 38. https://edicoes.ipp.pt/index.php/books/catalog/book/251 | |
| dc.identifier.doi | 10.26537/ed.p.porto.251 | |
| dc.identifier.isbn | 978-989-9226-20-3 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/32631 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Politema | |
| dc.relation | UID/50006/2025 | |
| dc.relation.hasversion | https://edicoes.ipp.pt/index.php/books/catalog/book/251 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | mir-151a-3p | |
| dc.subject | Electrochemical biosensor | |
| dc.subject | Neurodevelopmental disorders | |
| dc.title | Sensing the mind: label-free miRNA-based sensor as a diagnostic tool for neurodevelopmental disorders | eng |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2026-05-29 | |
| oaire.citation.conferencePlace | Porto | |
| oaire.citation.endPage | 38 | |
| oaire.citation.startPage | 38 | |
| oaire.citation.title | Book of Abstracts of the 8th Meeting on Medicinal Biotechnology | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Santos | |
| person.familyName | Almeida Rufo Pereira | |
| person.givenName | Marlene | |
| person.givenName | Eduarda | |
| person.identifier | 1508370 | |
| person.identifier.ciencia-id | 8311-B967-31C4 | |
| person.identifier.ciencia-id | 741D-D181-FD76 | |
| person.identifier.orcid | 0000-0001-5020-5942 | |
| person.identifier.orcid | 0000-0003-2721-7069 | |
| person.identifier.scopus-author-id | 57110502000 | |
| relation.isAuthorOfPublication | 8ce9ee39-a4c6-46ae-99e2-49397b550f1b | |
| relation.isAuthorOfPublication | d2a7908c-e396-4dcd-993c-303039a7f71c | |
| relation.isAuthorOfPublication.latestForDiscovery | 8ce9ee39-a4c6-46ae-99e2-49397b550f1b |