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Sensing the mind: label-free miRNA-based sensor as a diagnostic tool for neurodevelopmental disorders
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Orientador(es)
Resumo(s)
Mental health disorders, including Attention-Defi-cit/Hyperactivity Disorder (ADHD) and autism spec-trum disorder (ASD), are global public health concerns that lack accurate and fast diagnostic tools. Recent evidence highlights miR-151a-3p as a promising circu-lating biomarker, as its levels in plasma and saliva are associated with neurodevelopmental disorders. How-ever, current detection methods like RT-qPCR are ex-pensive and time-consuming, which creates a demand for innovative point-of-care solutions. Highly sensitive electrochemical biosensor for the direct detection of miR-151a-3p emerge as promising alternatives, in gold screen-printed electrodes functionalized with a specific DNA-151a-3p capture probe. The biosensor’s assembly and the hybridization events were moni-tored using cyclic voltammetry (CV) and electrochem-ical impedance spectroscopy (EIS). Preliminary results indicate that the biosensor exhibits high selectivity and sensitivity, distinguishing the target miR-151a-3p from non-complementary sequences within biologi-cally relevant concentration ranges. This label-free ap-proach offers a significant advantage over traditional assays by providing a cost-effective, fast, and portable diagnostic tool.
Descrição
Palavras-chave
mir-151a-3p Electrochemical biosensor Neurodevelopmental disorders
Contexto Educativo
Citação
Pereira, E., Santos, R., Prior, C., Santos Moreira, M., Teixeira, A. L., & Barroso, M. F. (2026). Sensing the mind: Label-free miRNA-based sensor as a diagnostic tool for neurodevelopmental disorders. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 38. https://edicoes.ipp.pt/index.php/books/catalog/book/251
Editora
Politema