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Resumo(s)
The nitration of Tyrosine residues in proteins is associated with nitrosative stress, resulting in the formation of 3-nitrotyrosine (3-NT). Different methods have been described for the quantification of this molecule. Regarding chromatographic methods, they seem to be very accurate, showing very good sensibility and specificity. Gas chromatography-based methods exhibit the highest sensibility, however a derivatization step prior analysis is required, which ends up being time-consuming for the analyst. Conversely, High Performance Liquid Chromatography (HPLC) may not require such derivatization.
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Contexto Educativo
Citação
Teixeira, D., Prudêncio, C., Fernandes, R., & Vieira, M. (2015). Development of a new method for the detection and quantification of 3-nitrotyrosine. In R. A. Silva, P. Baylina, F. Q. Vieira, C. Barrias, M. Rubim, T. Coelho, C. Prudêncio, & Â. Jesus (Eds.), II Congresso Internacional da Saúde Gaia Porto: Livro de Resumos (1st ed., Vol. 1, pp. 135). Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto.
Editora
Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto