Systematic overview of neuroanatomical differences in ADHD: Definitive evidence

Vieira De Melo, Bruno; Trigueiro, Maria João; Rodrigues, Pedro Pereira

http://hdl.handle.net/10400.22/13910

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Authors

Vieira De Melo, Bruno

Trigueiro, Maria João

Rodrigues, Pedro Pereira

Abstract(s)

Objectives: This article seeks to identify neuroanatomical differences in ADHD through an overview of systematic reviews that report encephalic differences compared to a control group in volume, area, activation likelihood or chemical composition. Methods: We conducted a systematic search using Cochrane guidelines and PRISMA criteria in PubMed, Scopus, Web of Science, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects. Results: Results revealed broad encephalic involvement that includes a functional frontal and cingulate hypoactivation and structural differences in corpus callosum, cerebellum and basal nuclei. Conclusions: ADHD symptoms might be due to a multi-network unbalanced functioning hypothesis.