| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 142.04 KB | Adobe PDF |
Advisor(s)
Abstract(s)
O presente trabalho descreve o estudo da actividad
e antimicrobiana de quarto derivados da quinoxalina N,N-dióxido: quinoxalina 1,4-dióxido, 2-metilquinoxalina 1,4-
dióxido, 6-cloro-2,3-dimetilquinoxalina 1,4-dióxido e 3-benzoil-2-metilquinoxalina 1,4-
dióxido contra as estirpes bacterianas Geobacillus stearothermophilus ATCC 10149,
Escherichia coli ATCC 25922, Escherichia coli HB101, Escherichia coli (blaTEM,
blaCTX-M) e Salmonella (blaCTX-M), assim como contra a estirpe de levedura
Saccharomyces cerevisiae PYCC 4072. A determinação da concentração mínima
inibitória (MIC) foi realizada pelo método de diluição. Os valores de MIC’s foram
estimados para cada composto e estirpe. Os resultados obtidos sugerem potenciais
novas drogas para quimioterapia.
The present work reports the study of the antimicrobial activity of four quinoxaline N,N-dioxide: quinoxaline 1,4-dioxide, 2-methylquinoxaline 1,4-dioxide, 6- chloro-2,3-dimethylquinoxaline 1,4-dioxide and 3-benzoyl-2-methylquinoxaline 1,4- dioxide against Geobacillus stearothermophilus ATCC 10149, Escherichia coli ATCC 25922, Escherichia coli HB101, Escherichia coli (blaTEM, blaCTX-M) and Salmonella (blaCTX-M) bacterial strains and also against the yeast Saccharomyces cerevisiae PYCC 4072. The determination of the minimal inhibitory concentration (MIC) was performed by the dilution method. The MIC values were estimated for each compound and each microorganism. The results obtained suggest potential new drugs for antimicrobial chemotherapy.
The present work reports the study of the antimicrobial activity of four quinoxaline N,N-dioxide: quinoxaline 1,4-dioxide, 2-methylquinoxaline 1,4-dioxide, 6- chloro-2,3-dimethylquinoxaline 1,4-dioxide and 3-benzoyl-2-methylquinoxaline 1,4- dioxide against Geobacillus stearothermophilus ATCC 10149, Escherichia coli ATCC 25922, Escherichia coli HB101, Escherichia coli (blaTEM, blaCTX-M) and Salmonella (blaCTX-M) bacterial strains and also against the yeast Saccharomyces cerevisiae PYCC 4072. The determination of the minimal inhibitory concentration (MIC) was performed by the dilution method. The MIC values were estimated for each compound and each microorganism. The results obtained suggest potential new drugs for antimicrobial chemotherapy.
Description
Keywords
Quinoxaline 1,4-dioxides Antimicrobial activity Inhibitory concentrations
Pedagogical Context
Citation
Publisher
Instituto Politécnico do Porto. Escola Superior de Tecnologia da Saúde do Porto - Politema