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Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation that leads to the destruction of cartilage and bone. Because it is an autoimmune disease, immunosuppressive therapy has shown to be the most effective and the widely used in this pathology. Tumor necrosis factor (TNF) antagonists are immunosuppressive drugs of the class of biological disease modifying antirheumatic drugs, which have been increasingly used for the treatment of rheumatoid arthritis due to their therapeutic benefits. These drugs act directly on the innate and adaptive immune response. However, since they are immunosuppressive drugs, they may increase the risk of opportunistic infection.
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Citação
Barbosa, A., & Santos, M. (2015). Risk of infection in rheumatoid arthritis patients treated with TNF-α antagonists: a systematic review. In R. A. Silva, P. Baylina, F. Q. Vieira, C. Barrias, M. Rubim, T. Coelho, C. Prudêncio, & Â. Jesus (Eds.), II Congresso Internacional da Saúde Gaia Porto: Livro de Resumos (1st ed., Vol. 1, pp. 115). Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto.
Editora
Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto