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Advisor(s)
Abstract(s)
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.
Description
Keywords
microRNAs E518K Thyroid cancer DGCR8 E518K
Citation
Rodrigues, L., Da Cruz Paula, A., Soares, P., & Vinagre, J. (2024). Unraveling the significance of DGCR8 and miRNAs in Thyroid Carcinoma. Cells, 13(7), Artigo 7. https://doi.org/10.3390/cells13070561
Publisher
MDPI