Publication
Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma
| dc.contributor.author | Rodrigues, Lia | |
| dc.contributor.author | Paula, Arnaud Da Cruz | |
| dc.contributor.author | Soares, Paula | |
| dc.contributor.author | Vinagre, João | |
| dc.date.accessioned | 2024-05-20T13:18:38Z | |
| dc.date.available | 2024-05-20T13:18:38Z | |
| dc.date.issued | 2024-03-22 | |
| dc.description.abstract | MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Rodrigues, L., Da Cruz Paula, A., Soares, P., & Vinagre, J. (2024). Unraveling the significance of DGCR8 and miRNAs in Thyroid Carcinoma. Cells, 13(7), Artigo 7. https://doi.org/10.3390/cells13070561 | pt_PT |
| dc.identifier.doi | 10.3390/cells13070561 | pt_PT |
| dc.identifier.eissn | 2073-4409 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/25531 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | FCT—Fundação para a Ciência e Tecnologia, I.P., 2023.03099.BD, 2022.00276.CEECIND, PTDC/MED-ONC/0531/2021—CTRL + ALT + CEL: How ATRX Controls an Alternative Program in the β-cell. Institute for Research and Innovation in Health Sciences (UID/BIM/04293/2019); “Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets”- NORTE-01-0145-FEDER-000051, “The Porto Comprehensive Cancer Center” - NORTE-01-0145-FEDER-072678—Consórcio PORTO.CCC—Porto.Comprehensive Cancer Center Raquel Seruca. “2022-C05IO101-02— Agenda Illiance (Bosch, project no. 46)—PPS4—OLI health” - C644919832-00000035, PRR—Plano de Recuperação e Resiliência e pelos Fundos Europeus NextGenerationEU, através do sistema de incentivos “Agendas para a Inovação Empresarial”. | pt_PT |
| dc.relation.publisherversion | https://www.mdpi.com/2073-4409/13/7/561 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | microRNAs E518K | pt_PT |
| dc.subject | Thyroid cancer | pt_PT |
| dc.subject | DGCR8 | pt_PT |
| dc.subject | E518K | pt_PT |
| dc.title | Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 14 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | Cells | pt_PT |
| oaire.citation.volume | 13(7) | pt_PT |
| person.familyName | Rodrigues | |
| person.givenName | Lia | |
| person.identifier | 2587034 | |
| person.identifier.ciencia-id | E413-028E-86EB | |
| person.identifier.orcid | 0000-0002-3718-1111 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 842411e6-9342-46d6-974a-740eb3dff276 | |
| relation.isAuthorOfPublication.latestForDiscovery | 842411e6-9342-46d6-974a-740eb3dff276 |