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Authors
Fernandes, Sara
Cruz, Agostinho
Vieira da Silva, Manuela
Amorim, Manuela
Vieira, Mónica
Advisor(s)
Abstract(s)
The use of anticancer drugs is not restricted to a single type of drug (Connor et al. , 1999; Suspiro & Prista, 2012). These are varied and present diverse mechanisms of action, which may be causes of occupational exposure. Despite the restricted and controlled use of cytotoxic agents, the risk involved is not confined to individuals who administer them but also to all health care professionals and general population directly or indirectly in contact with them (Suspiro & Prista, 2012). The presence of pharmaceuticals products in natural surface waters and in the effluent sewage treatment plants have been reported since 1980s. More recently, these products have been detected in ground and drinking water. However, there is little information about the risks these drugs and their metabolites in the water, have, for the human health (Ferrando-Climentet al. , 2013).There are few published studies with detailed information about the significance of pharmaceuticals compounds in water for humans (Ferrando- Climentet al. , 2013). The major concern with genotoxic/carcinogenic pharmaceuticals compounds is a cancer risk, at any level of exposure because there is no threshold dose below which no carcinogenic effect may occur (Garcia-AC et al., 2011). The pharmaceutical compounds are excreted to wastewater and become potential water contaminants. Currently, very little is known about the presence and elimination process of cytostatic drugs in wastewater treatment plants. The lack of methods and knowledge about the specific risk of pharmaceutical products in aquatic environment may be consider a public health problem.
Description
Keywords
Anticancerdrugs Occupational exposure
Citation
Teles, L., Fernandes, S., Cruz, A., Silva, M., Amorim, M., Vieira, M., & Barros, P. (2014). Occupational and environmental exposure to anticancer drugs. ICEH14 /3rd International Congress of Environmental Health: Proceedings Book, 1, 208–209.
Publisher
Área Científica da Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto