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Tackling bacterial resistance using antibiotics as ionic liquids and organic salts

2019-11-12Conference object Open access
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dc.contributor.authorSantos, Miguel M.
dc.contributor.authorGrilo, Inês R.
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorMadeira, Diogo A.
dc.contributor.authorSoares, Bárbara M.
dc.contributor.authorInácio, Núria
dc.contributor.authorPinheiro, Luís
dc.contributor.authorPetrovski, Zeljko
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorSobral, Rita G.
dc.contributor.authorBranco, Luís C.
dc.date.accessioned2023-10-25T13:17:04Z
dc.date.available2023-10-25T13:17:04Z
dc.date.issued2019-11-12
dc.description.abstractBacterial resistance to current antibiotics has a major impact on worldwide human health, leading to 700K deaths every year. The development of novel antibiotics did not present significant progress, namely regarding clinical trials, over the last years due to low returns. Thus, innovative alternatives must be devised to tackle the continuous rise of antimicrobial resistance. Ionic Liquids and Organic Salts from Active Pharmaceutical Ingredients (API-OSILs) have risen in academia for over 10 years as an efficient formulation for drugs with low bioavailability and permeability, as well as reduction or elimination of polymorphism, thereby potentially enhancing their pharmaceutical efficiency. To the best of our knowledge, our group is the first to perform research on the development of API-OSILs from antibiotics as a way to improve their efficiency. More specifically, we have successfully combined ampicillin, penicillin and amoxicillin as anions with biocompatible organic cations such as choline, alkylpyridiniums and alkylimidazoliums. In this communication, we present our latest developments in the synthesis and physicochemical (DSC) characterization of OSILs from these antibiotics, in addition to in vitro antimicrobial activity data, in particular towards MRSA and multi-resistant E. coli, as well as sensitive strains of gram-positive and gram-negative bacteria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerraz, R., & Prudêncio, C. (2019, novembro). Tackling bacterial resistance using antibiotics as ionic liquids and organic salts [Poster]. 5th International Eletronic Conference on Medicinal Chemistry. https://sciforum.net/manuscripts/6414/slides.pdfpt_PT
dc.identifier.doi10.3390/ECMC2019-06414pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.22/23773
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationFCT-MCTES (PTDC/QUIQOR/ 32406/2017, PTDC/BIA-MIC/31645/2017, PEst-C/LA0006/2013, IF/0041/2013/CP1161/CT00), by the Associate Laboratory for Green Chemistry LAQV and by the Unidade de Ciências Biomoleculares Aplicadas-UCIBIO which are financed by national funds from FCT/MCTES (UID/QUI/50006/2013 and UID/Multi/04378/2013, respectively) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145- FEDER-007265 and POCI-01-0145-FEDER-007728, respectively).pt_PT
dc.relation.publisherversionhttps://sciforum.net/paper/view/6414pt_PT
dc.subjectActive pharmaceutical ingredientspt_PT
dc.subjectAPI-OSILspt_PT
dc.subjectAntibioticspt_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectIonic liquidspt_PT
dc.subjectOrganic saltspt_PT
dc.subjectPolymorphismpt_PT
dc.titleTackling bacterial resistance using antibiotics as ionic liquids and organic saltspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage18pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.title5th International Eletronic Conference on Medicinal Chemistry - Pharmaceuticalspt_PT
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3

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