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Advisor(s)
Abstract(s)
Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood vessels from preexisting ones and is recognized as a key event in cell proliferation and carcinogenesis and spread of malignant lesions. A growing amount of evidence points to angiogenesis playing a key role in schistosomiasis-associated bladder cancer. Thus, identifying biomarkers of this process plays an important role in the study of cancer. Here, we review recent findings on the role of angiogenesis in bladder cancer and the growth factors that induce and assist in their development, particularly SCC of the bladder associated to urogenital schistosomiasis.
Description
Keywords
Animals Biomarkers, Tumor Carcinoma, Squamous Cell Humans Lymphangiogenesis Neovascularization, Pathologic Schistosoma haematobium Schistosomiasis haematobia Urinary Bladder Neoplasms Vascular Endothelial Growth Factor A
Citation
Dematei A, Fernandes R, Soares R, Alves H, Richter J, Botelho MC. Angiogenesis inSchistosoma haematobium-associated bladder cancer. APMIS 2017; 125: 1056–1062
Publisher
John Wiley and Sons