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Angiogenesis in Schistosoma haematobium-associated urinary bladder cancer

2017Journal article Open access
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dc.contributor.authorDematei, Anderson
dc.contributor.authorFernandes, Rúben
dc.contributor.authorSoares, Raquel
dc.contributor.authorAlves, Helena
dc.contributor.authorRichter, Joachim
dc.contributor.authorBotelho, Monica C.
dc.date.accessioned2019-07-01T13:29:49Z
dc.date.available2019-07-01T13:29:49Z
dc.date.issued2017
dc.description.abstractSchistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood vessels from preexisting ones and is recognized as a key event in cell proliferation and carcinogenesis and spread of malignant lesions. A growing amount of evidence points to angiogenesis playing a key role in schistosomiasis-associated bladder cancer. Thus, identifying biomarkers of this process plays an important role in the study of cancer. Here, we review recent findings on the role of angiogenesis in bladder cancer and the growth factors that induce and assist in their development, particularly SCC of the bladder associated to urogenital schistosomiasis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDematei A, Fernandes R, Soares R, Alves H, Richter J, Botelho MC. Angiogenesis inSchistosoma haematobium-associated bladder cancer. APMIS 2017; 125: 1056–1062pt_PT
dc.identifier.doi10.1111/apm.12756pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14184
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley and Sonspt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.12756pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkers, Tumorpt_PT
dc.subjectCarcinoma, Squamous Cellpt_PT
dc.subjectHumanspt_PT
dc.subjectLymphangiogenesispt_PT
dc.subjectNeovascularization, Pathologicpt_PT
dc.subjectSchistosoma haematobiumpt_PT
dc.subjectSchistosomiasis haematobiapt_PT
dc.subjectUrinary Bladder Neoplasmspt_PT
dc.subjectVascular Endothelial Growth Factor Apt_PT
dc.titleAngiogenesis in Schistosoma haematobium-associated urinary bladder cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1062pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1056pt_PT
oaire.citation.titleAPMISpt_PT
oaire.citation.volume125pt_PT
person.familyNameFernandes
person.givenNameRúben
person.identifier635792
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0001-8933-3984
person.identifier.scopus-author-id57640135700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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