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Advisor(s)
Abstract(s)
MMP7, also known as matrix metalloproteinase 7, is a biomarker for oncogenic activity in a variety of tumour types. As part of the zinc-dependent endopeptidases group, it can break down practically all protein components found in the extracellular matrix1. CdTe MPA-Capped Quantum Dots (CdTe@MPA QDs) are luminescent nanoparticles with exceptional optical features as customized particle sizes and narrow emission spectra. They can be integrated into sensing systems for the sensitive and selective detection of metal ions, biomarkers, and antibiotics2. QDs can be functionalized by in situ polymerization, which combines monomers, crosslinkers, and proteins to create recognition cavities. Upon rebinding with the target biomarker, these
cavities demonstrate biomimetic recognition sites complementary to the target biomolecule. The presence of the target leads to fluorescence quenching, of the functionalized QDs with MIPs, thus allowing for a simple and straightforward method for the selective quantification of the biomolecule.
Description
Keywords
MMP7 biomarker Sensors
Pedagogical Context
Citation
Oliveira, P., & Piloto, A.M.L. (2024, May 23-24). Quantum dot-based optical sensor for MMP7 biomarker with molecularly imprinted polymers [Poster presentation]. VII iBiMED Symposium: Sharing science, inspiring progress, University of Aveiro, Aveiro, Portugal.