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Introduction: The polymer PEI-MP (polyethyleneiminomethyl phosphonic acid) might be labelled with 99mTc. It was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling, however in biodistribution studies performed with different PEI-MP/radionuclides, was obvious that the bladder wall was a target organ [1-3], demonstrating a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of 99mTc-PEI-MP for diagnosis of bladder carcinoma, evaluating in vitro and in vivo the biokinetics and biodistribution of 99mTc-PEI-MP