Repository logo
 
Publication

Cellular senescense: an overview on characteristics, effects and senotherapy

2024-11-26Master thesis Restricted access
Simple item page
dc.contributor.advisorCastro, José Pedro
dc.contributor.advisorSousa, Maria Manuela Amorim de Silva e
dc.contributor.advisorLamas, Maria Céu Ribeiro
dc.contributor.authorFerreira, Patrícia dos Santos
dc.date.accessioned2025-02-11T14:20:36Z
dc.date.available2025-02-11T14:20:36Z
dc.date.issued2024-11-26
dc.date.submitted2024-11-26
dc.description.abstractCellular senescence is defined as part of the aging process that can be found throughout the life cycle and, i tis linked to age-related chronic pathologies like diabetes, Alzheimer’s, Osteoporosis, Cancer and many others. For several years, cellular senescence has been portrayed as detrimental, shadowing any potential benefits of senescence. It is of extreme importance to understand what changes happen in the cells during senescence. It is of extreme importance to understand what changes happen in the cells during senescence and grasp their role in aging to fully understand its role in adaptation and damage features. The goal of this study was to conduct a review of the state of the art in cellular senescence, types, main charateristics and its role in health and disease. Using the PRISMA methodology, a query with specified keywords was used. Fourteen studies were analyzed. It is importante to highlight that the use of fibroblasts as a suitable model to develop studies, the role of BAFF signaling as a future reference in senotherapy studies and probe XZ1208 as a new method of identification of senescente cells.por
dc.identifier.tid203850726
dc.identifier.urihttp://hdl.handle.net/10400.22/29465
dc.language.isoeng
dc.rights.uriN/A
dc.subjectCellular senescense
dc.subjectSenescense associated secretory
dc.subjectAging
dc.subjectSecretory diseases
dc.subjectWound healing
dc.titleCellular senescense: an overview on characteristics, effects and senotherapypor
dc.typemaster thesis
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Dissertacao_MACSP_PatriciaFerreira_V.Final.pdf
Size:
7.49 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - DM - Análises Clínicas e Saúde Pública