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Efficacy and safety of topical antifungals used in the treatment of vaginal fungal infections: A Systematic Review of clinical trials published between 2018 and 2024

2025-10Documento de conferência Acesso aberto
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dc.contributor.authorOliveira, Tiago
dc.contributor.authorJesus, Ângelo
dc.contributor.authorMoreira, Fernando
dc.contributor.authorJesus, Ângelo
dc.contributor.authorMoreira, Fernando
dc.date.accessioned2026-09-16T09:29:14Z
dc.date.available2026-09-16T09:29:14Z
dc.date.issued2025-10
dc.description.abstractGenitourinary infections are clinically important due to the discomforting symptoms, psychological repercussions, and the ease of acquisition and transmission of the human immunodeficiency virus [1]. Vulvovaginal candidiasis is the second leading cause of vaginitis and affects 75% of women worldwide. The aim of this study is to analyse the efficacy and safety of the latest topical antifungals for vaginal fungal infections. Literature searches were performed in the PubMed, Scopus, LILACS, and IBECS databases, according to the PRISMA guidelines. Following the removal of duplicate records, a total of 1326 studies were screened based on predefined inclusion and exclusion criteria. Studies published between 2018 and 2024 were included. This systematic review is registered in the PROSPERO database under the registration number CRD42024527596. Ultimately, 18 studies fulfilled these criteria and were incorporated into the systematic review. Of the 18 clinical trials analysed, 16 assessed topical application alternatives to conventional treatment of genitourinary infections. The comparison between the investigational products and the control groups demonstrated that, overall, the tested products exhibit efficacy comparable to or greater than that of conventional treatments in the management of genitourinary infections. In 14 of the 18 clinical trials included in the systematic review, no adverse effects were reported. Natural topical treatments for vulvovaginal candidiasis show promising efficacy, better tolerability, and greater patient convenience, suggesting potential to improve adherence and contributing to strategies against antifungal resistance.eng
dc.identifier.citationOliveira, T., Jesus, A., & Moreira, F. (2025). Efficacy and safety of topical antifungals used in the treatment of vaginal fungal infections: A Systematic Review of clinical trials published between 2018 and 2024. 13th APLF Annual Conference, TherapeuTic advances in drug safety 16(S1), 25. https://journals.sagepub.com/doi/epub/10.1177/20420986251379201
dc.identifier.doi10.1177/20420986251379201
dc.identifier.eissn2042-0994
dc.identifier.issn2042-0986
dc.identifier.urihttp://hdl.handle.net/10400.22/32707
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relation.hasversionhttps://journals.sagepub.com/doi/10.1177/20420986251379201
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectGenitourinary infections
dc.subjectVulvovaginal candidiasis
dc.subjectAntifungals
dc.titleEfficacy and safety of topical antifungals used in the treatment of vaginal fungal infections: A Systematic Review of clinical trials published between 2018 and 2024eng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2025-10
oaire.citation.conferencePlaceAveiro
oaire.citation.issueS1
oaire.citation.startPage25
oaire.citation.title13th APLF Annual Conference - TherapeuTic advances in drug safety
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameJesus
person.familyNameMoreira
person.givenNameÂngelo
person.givenNameFernando
person.identifier2947760
person.identifier.ciencia-idA91F-3585-4F42
person.identifier.ciencia-id5F16-AB92-94D0
person.identifier.orcid0000-0003-3972-8253
person.identifier.orcid0000-0002-3452-1459
person.identifier.ridA-4404-2012
person.identifier.scopus-author-id56153841300
relation.isAuthorOfPublication1cbff3da-9800-4bd7-8d84-fd8d9ca819b2
relation.isAuthorOfPublication81213e80-09a5-4655-93dc-e54199edb2fe
relation.isAuthorOfPublication.latestForDiscovery1cbff3da-9800-4bd7-8d84-fd8d9ca819b2

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