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Advisor(s)
Abstract(s)
(Introduction) Cancer is a global health challenge, where early detection is crucial to increasing survival rates [1]. Non-invasive, rapid, and affordable diagnostic methods are urgently needed. Immunosensors emerge as promising alternatives to traditional methods such as ELISA, allowing point-of-care (PoC) analyses [2]. This study introduces a fluorescent probe using cadmium telluride quantum dots (CdTe@MPA QDs) to detect the pancreatic cancer biomarker CA 19-9. With the increasing CA 19-9 concentrations, the fluorescence intensity of green-, orange-, and red-emitting QDs@conjugates was reduced, creating a visible colour gradient under a 365 nm UV lamp. The method, suitable for serum analysis, is highly sensitive and selective, with a detection range of 0.31 to 501.9 U mL-1 and analyzed using ImageJ software. These immunosensors offer significant potential for cancer biomarker detection in clinical diagnostics.
Description
Keywords
Diagnosis methods of cancer Immunosensors Quantum dots Cancer biomarkers
Citation
Oliveira, D., & Piloto, A.M.L. (2024, Jun. 23-26). Development of an immunosensor based on quantum dots with different emissions for the detection of cancer biomarkers [Poster presentation]. RICI X - 10th Iberian Meeting on Colloids and Interfaces, Coimbra, Portugal