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Potential activity of withanolides in breast cancer treatment: a systematic review

2025-10Póster não publicado nas atas da conferência Acesso aberto
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dc.contributor.authorMoreira, Ana Margarida
dc.contributor.authorOliveira, Rita Ferraz
dc.contributor.authorPinho, Cláudia
dc.contributor.authorCorreia, Patrícia
dc.contributor.authorFerraz Oliveira, Rita
dc.contributor.authorPinho, Cláudia
dc.contributor.authorCorreia, Patrícia Carla dos Santos Correia
dc.date.accessioned2026-09-21T13:49:46Z
dc.date.available2026-09-21T13:49:46Z
dc.date.issued2025-10
dc.description.abstractPortuguese female population data from 2021 indicate that 31.6% of all tumours were breast cancer (BC), with 8,714 new cases reported [1]. Withanolides, a group of steroidal lactones found in plants such as Withania somnifera, Physalis peruviana, and Tubocapsicum anomalum, exhibit potential anticancer activity and are considered promising compounds for the treatment of BC [2]. Discuss the effectiveness and the potential mechanisms of action of withanolides in the treatment of BC. Methods: Following PRISMA guidelines, a systematic review was conducted to evaluate in vitro and in vivo activity of natural/synthetic withanolides in BC, using original articles published in English (until December 2024) found in ScienceDirect® and Pubmed® databases and using the keywords “withanolides” and “breast cancer”. A total of 34 studies were analysed (24 in vitro, three in vivo, seven combining both type of approaches), with withaferin A being the predominant compound. The effectiveness of withanolides was evaluated using different approaches, such as cell viability/cell proliferation assays and analysis of apoptosis. The doses of withanolides used in studies and cancer cell lines (e.g., MCF-7, MDA-MB-231) ranged typically from 2 to 5 μM (in vitro studies) and from 4 to 8 mg/kg (in vivo studies). The mechanisms of action included cell cycle arrest (e.g., at the G2/M phase), modulation of oxidative stress, induction of apoptosis, inhibition of cell proliferation. Further studies are needed to confirm the results in clinical trials and to assess the potential of this group of steroidal lactones. Keywords: Withania somnifera, withaferin A, breast cancer Acknowledgements This work received financial support from the PT national funds (FCT/MECI, Fundação para a Ciência e Tecnologia and Ministério da Educação, Ciência e Inovação) through the project UID/50006 -Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos.eng
dc.identifier.citationMoreira, A. M., Oliveira, R. F., Pinho, C., & Correia, P. (2025). Potential activity of withanolides in breast cancer treatment: A systematic review. 13th APLF Annual Conference, TherapeuTic advances in drug safety 16(S1), 69. https://journals.sagepub.com/doi/epub/10.1177/20420986251379201
dc.identifier.doi10.1177/20420986251379201
dc.identifier.eissn2042-0994
dc.identifier.issn2042-0986
dc.identifier.urihttp://hdl.handle.net/10400.22/32756
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relationUID/50006
dc.relation.hasversionhttps://journals.sagepub.com/doi/epub/10.1177/20420986251379201
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectWithania somnifera
dc.subjectWithaferin A
dc.subjectBreast cancer
dc.titlePotential activity of withanolides in breast cancer treatment: a systematic revieweng
dc.typeconference poster not in proceedings
dspace.entity.typePublication
oaire.citation.conferenceDate2025-10
oaire.citation.conferencePlaceAveiro
oaire.citation.issueS1
oaire.citation.startPage69
oaire.citation.title13th APLF Annual Conference TherapeuTic advances in drug safety
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFerraz Oliveira
person.familyNamePinho
person.familyNameCorreia
person.givenNameRita
person.givenNameCláudia
person.givenNamePatrícia Carla dos Santos Correia
person.identifier.ciencia-idFD1F-2E0C-1254
person.identifier.ciencia-id8B1B-A0D9-B6E4
person.identifier.ciencia-id221F-5A5F-BFC9
person.identifier.orcid0000-0003-3933-5740
person.identifier.orcid0000-0002-3157-3712
person.identifier.orcid0000-0001-7869-7977
relation.isAuthorOfPublication6c1b7213-1303-47eb-bfa7-ecbef6a9b8d9
relation.isAuthorOfPublication01c994b8-cb20-43a8-947c-d2b978283944
relation.isAuthorOfPublication655ab14f-f60f-42c5-8c8a-19d5257ff5f6
relation.isAuthorOfPublication.latestForDiscovery6c1b7213-1303-47eb-bfa7-ecbef6a9b8d9

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