| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 241.05 KB | Adobe PDF |
Advisor(s)
Abstract(s)
A dual-emissive fluorescent probe has been developed for the sensitive and selective detection of matrix metalloproteinase 7 (MMP7), a protein biomarker associated with pancreatic cancer1,2. The resultant materials were designated as imprinted ratiometric hydrogels (imprinted rHGs). The fluorescence quenching of the imprinted rHGs occurred with increasing concentrations of MMP7, showing linearity in the range [1.49 x 10-11 – 1.92 x 10-9] g/mL in 1000-fold diluted human serum in PBS 10mM pH 5.8. Overall, the imprinted rHGs developed in this work presented increased selectivity for the MMP7 protein over raw emitting QDs nanoparticles and higher sensitivity comparatively to the non-imprinted rHGs.
Description
Keywords
Citation
Piloto, A.M.L., Ribeiro, D.S.M., Santos, J.L.M., & Sales, G. (2024, Jun. 23-26). Sensitive ratiometric imprinted hydrogel for the detection of matrix metalloproteinase 7 (MMP7) biomarker [Abstract]. RICI X - 10th Iberian Meeting on Colloids and Interfaces, Coimbra, Portugal