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Synthesis od new surface-active ionic liquids derived from antimalarial drugs and bile acids

2022-11Conference object Open access
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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorOliveira, Isabel
dc.contributor.authorDuarte, Denise
dc.contributor.authorMoita, Diana
dc.contributor.authorPrudêncio, Miguel
dc.contributor.authorNogueira, Fátima
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorMarques, Eduardo F.
dc.contributor.authorGomes, Paula
dc.date.accessioned2025-01-07T17:21:51Z
dc.date.available2025-01-07T17:21:51Z
dc.date.issued2022-11
dc.description.abstractMalaria is a parasitic disease that occurs mostly in low-income countries, thus its containment or, ultimately, eradication demands new methodologies and synthetic strategies that are simple and inexpensive. Ionic liquids (ILs) may assume a prominent role in this scenario, as they are catching the attention of the Medicinal Chemistry community owing to their intrinsic biological activity and affordable synthesis through straightforward methods. In this context, our focus consists of using an acid-base reaction between basic antimalarial aminoquinolines, such as chloroquine and primaquine, and natural amphiphilic acids, such as fatty and bile acids. The resulting ILs are expected to preserve the parent aminoquinolines' antimalarial action, while retaining the surface activity of the parent amphiphilic acids, thus facilitating the permeation of the whole IL structure through important biological barriers. In other words, our aim is to develop surface-active ionic liquids (SAILs) with intrinsic antimalarial properties. Results obtained thus far will be presented, demonstrating that SAILs can be produced which are active against different stages of malaria parasite development in the human host. Self-aggregation properties of these SAILs are currently under investigation and will be timely reported.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. T., Oliveira, I., Duarte, D., Moita, D., Prudêncio, M., Nogueira, F., Teixeira, C., Ferraz, R., Marques, E. F., & Gomes, P. (2022). Synthesis od new surface-active ionic liquids derived from antimalarial drugs and bile acids. Libro de resúmenes del XXVI Encontro Internacional Galego‐Portugués de Química., 578. https://www.colquiga.org/_files/ugd/398543_55f54cb41f0849d2b908563d15c992b5.pdfpt_PT
dc.identifier.isbn978-84-09-45895-0
dc.identifier.urihttp://hdl.handle.net/10400.22/27031
dc.language.isoengpt_PT
dc.publisherColegio Oficial de Químicos de Galiciapt_PT
dc.relationThis work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019. The authors would like to thank to PTDC/BTMSAL/29786/2017, UIDB/00081/2020, POCI-01-0145- FEDER-006980 and NORTE-01-0145-FEDER-000028. ATS thanks FCT and Sociedade Portuguesa de Química for her doctoral grant SFRH/BD/150649/2020.pt_PT
dc.relation.publisherversionhttps://www.colquiga.org/_files/ugd/398543_55f54cb41f0849d2b908563d15c992b5.pdfpt_PT
dc.subjectMalariapt_PT
dc.subjectParasitic diseasept_PT
dc.titleSynthesis od new surface-active ionic liquids derived from antimalarial drugs and bile acidspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSantiago de Compostelapt_PT
oaire.citation.startPage578pt_PT
oaire.citation.titleLibro de resúmenes del XXVI Encontro Internacional Galego‐Portugués de Química.pt_PT
person.familyNameFerraz
person.givenNameRicardo
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.orcid0000-0002-1761-117X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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