Synthesis od new surface-active ionic liquids derived from antimalarial drugs and bile acids

Malaria is a parasitic disease that occurs mostly in low-income countries, thus its containment or, ultimately, eradication demands new methodologies and synthetic strategies that are simple and inexpensive. Ionic liquids (ILs) may assume a prominent role in this scenario, as they are catching the attention of the Medicinal Chemistry community owing to their intrinsic biological activity and affordable synthesis through straightforward methods. In this context, our focus consists of using an acid-base reaction between basic antimalarial aminoquinolines, such as chloroquine and primaquine, and natural amphiphilic acids, such as fatty and bile acids. The resulting ILs are expected to preserve the parent aminoquinolines' antimalarial action, while retaining the surface activity of the parent amphiphilic acids, thus facilitating the permeation of the whole IL structure through important biological barriers. In other words, our aim is to develop surface-active ionic liquids (SAILs) with intrinsic antimalarial properties. Results obtained thus far will be presented, demonstrating that SAILs can be produced which are active against different stages of malaria parasite development in the human host. Self-aggregation properties of these SAILs are currently under investigation and will be timely reported.

Keywords

Malaria Parasitic disease

URI

http://hdl.handle.net/10400.22/27031

Citation

Silva, A. T., Oliveira, I., Duarte, D., Moita, D., Prudêncio, M., Nogueira, F., Teixeira, C., Ferraz, R., Marques, E. F., & Gomes, P. (2022). Synthesis od new surface-active ionic liquids derived from antimalarial drugs and bile acids. Libro de resúmenes del XXVI Encontro Internacional Galego‐Portugués de Química., 578. https://www.colquiga.org/_files/ugd/398543_55f54cb41f0849d2b908563d15c992b5.pdf