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- Livro de atas do IX Colóquio de FarmáciaPublication . Cruz, Agostinho; Cunha, Agostinho; Oliveira, Ana Isabel; Jesus, Ângelo; Pinho, Cláudia; Santos, Marlene; Correia, Patrícia Carla dos Santos; Ferraz Oliveira, RitaLivro de Atas do “IX Colóquio de Farmácia”: “Envelhecimento e Saúde” da “9 th Pharmacy Academic Conference Proceedings” em Abril de 2013.
- In vitro antibacterial and cytotoxic activity of Laurobasidium lauri extractsPublication . Silva, L.; Oliveira, Ana Isabel; Moreira, Fernando; Ferraz Oliveira, Rita; Pinho, CláudiaPlants and mushrooms have been used as medicines for many years, as a source of antibi-otics, antineoplastics, among others. Research have been conducted on the medicinal uses of Portu-guese plants, however, the therapeutic potentials of some of these plants used in traditional medicine, has remained unexploited. This study aims to evaluate antibacterial and cytotoxic activities, in vitro, of Laurobasidium lauri, a well-known fungus used in folk medicine on Madeira Island. An experimental study was performed using two extracts (aqueous and ethanolic 55% (V/V)) of the fun-gus isolated and in combination with three medicinal plants (Parietaria judaica, Polygonum aviculare, and Peperomia galioides). The antibacterial activity was evaluated against Escherichia coliand Staphy-lococcus aureus, through disc diffusion and broth microdilution methods. Cytotoxicity was evaluated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Regarding the disc diffusion method E. coliwas not susceptible to any of the extracts, except for the antibiotic (41.0 ± 1.0 mm). However,S. aureus, when subjected to 10 mg/ml of the ethanolic extracts of L. lauri(isolated and in combination) exhibited an inhibition with a diameter of 16,3 ± 2,5 mm and 12,0 ± 1,7 mm, respec-tively, when compared to the control, ciprofloxacin (24,0±1,0 mm). Also, the ethanolic extract of the isolated fungus had the best value of minimum inhibitory concentration (MIC) for S. aureus(MIC = 0.078125 mg/mL). The ethanolic extract of the fungus in combination with medicinal plants showed greater cytotoxic action on lung cancer cells A549 (IC50 = 48.3±1.0 μg/mL). The fungus presented cytotoxic and antibacterial potential, and the results observed may be related to some bioactive compounds (e.g., costunolide and dehydrocostuslactone, two natural sesquiterpene lactones present in Laurustrees, where the fungus grows). However, more research is needed to confirm these biological activities and mechanisms of action.
- O conceito da qualidade nos produtos à base de Ginkgo biloba comercializados em PortugalPublication . Pinho, Cláudia; Correia, Patrícia; Cunha, Agostinho; Jesus, Ângelo; Oliveira, Ana Isabel; Ferraz Oliveira, Rita; Santos, Marlene; Cruz, AgostinhoO extracto de Ginkgo biloba é o produto fitoterápico mais vendido na Europa. Em Portugal e muitos países, a maioria dos produtos à base de plantas são comercializados como suplementos alimentares, não estando garantidos, parâmetros de qualidade, segurança e eficácia. Realizouse um estudo, com recolha de informações, tendo por base uma amostra de 50 produtos à base de ginkgo. Da análise, verificou-se que 94% podiam ser encontrados à venda na internet, e desse total, 89% possuíam informação on-line quanto à composição. Apenas 40% referem a utilização do extracto padronizado de ginkgo e muitos recomendam doses superiores às referidas como terapêuticas.
- Phytochemical screening of aqueous and hydroalcoholic extractive solutions of Taraxacum hispanicum leavesPublication . Laranjeira, Cátia; Oliveira, Ana Isabel; Ferraz Oliveira, Rita; Cruz, Agostinho; Pinho, CláudiaPlants of the genus Taraxacum (dandelion) are a source of diverse phytochemicals, and its biological activities can be exploited in different areas of human health. Phytochemical composition of dandelion, in particular T. officinale, has been extensively studied over the years. However, to date no studies have been performed regarding T. hispanicum phytochemical characterization, which is a common South European specie of Taraxacum.
- Phytochemical screening and antioxidant activity of green tea (Camellia sinensis) infusions commercialized in portugalPublication . Silva, Inês; Gonçalves, Joana; Carmo, Juliana; Cruz, Agostinho; Oliveira, Ana Isabel; Ferraz Oliveira, Rita; Pinho, CláudiaNatural antioxidant products, like green tea (Camellia sinensis) have gained popularity worldwide and new products claiming antioxidant activity are frequent in the dietary supplement industry. However, information regarding the antioxidant properties of these products, in the labels, is usually scarce. In addition, the antioxidant properties of commercial teas were not investigated in detail. Therefore, the present study aims to investigate the phytochemical and antioxidant activity of C. sinensis infusions.
- Dermocosmética em oncologia: cuidados diários de rosto em mulheres com historial clínico de neoplasia de mamaPublication . Pereira, Ana; Neto, Sara; Oliveira, Rita Ferraz de; Pinho, Cláudia; Oliveira, Ana IsabelA pele, funcionando como barreira protetora contra agentes do meio ambiente, deve manter-se saudável possuindo cuidados como limpeza, esfoliação e hidratação. Tendo sido o cancro da mama considerado o mais incidente em Portugal no sexo feminino em 2010 e os tratamentos oncológicos realizados provocarem efeitos como xerose, prurido e sensibilidade solar, é imprescindível um aconselhamento dermatológico por parte de um profissional de saúde para melhorar a qualidade de vida do doente. O presente estudo pretendeu avaliar se existe o aconselhamento pelo profissional e a adoção de medidas relacionadas com os sintomas cutâneos. Também se pretendeu verificar a influência dos tratamentos oncológicos na saúde cutânea de doentes com cancro da mama.
- Polypharmacy and drug interactions in older patients with cancer receiving chemotherapy: associated factorsPublication . Ferraz Oliveira, Rita; Oliveira, Ana Isabel; Cruz, Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, FranciscoPolypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac risk, and high-risk medications) were also analysed. ents (ANAs); it was conducted in three hospitals from the north of Portugal. Data collection was obtained using self-reports and medical records. DDIs were identifed and classifed using Micromedex® software. Descriptive and association analyze statistics were performed. Statistical hypothesis tests with p value less than 0.05 were considered signifcant. All statistical procedures and analysis were performed with R version 4.1.3. We enrolled 552 patients. Polypharmacy prevalence was 88.40%; 76.45% and 56.16% of the patients presented with DDIs and SDIs, respectively. SDIs with ANAs were found in 21.20% of the patients. High-risk medications were associated with a higher risk of polypharmacy, DDIs, and SDIs. Polypharmacy and DDIs were higher in patients with hypertension or diabetes. SDIs were higher in patients with diabetes. Polypharmacy, potential DDIs and SDIs were highly prevalent in older adults with cancer. A careful review of the medication administered is necessary to decrease it. These fndings warrant further research to optimize medication in this population and decrease problems related to medication, which may lead to emergency room visits and hospitalisations, compromising patient safety and/or ongoing treatments.
- Physicochemical properties and antioxidant activity of portuguese craft beers and raw materialsPublication . Silva, Sara; Oliveira, Ana Isabel; Cruz, Agostinho; Ferraz Oliveira, Rita; Almeida, Rubim; Pinho, CláudiaThere is an increase in the popularity of craft beer, which is produced by small, independent, and traditional breweries. Since craft beer popularity is rising in Portugal this research focused on assessing physicochemical parameters, total phenolic content (TPC) and the antioxidant capacity of Portuguese craft beers and raw materials used in beer production. In this experimental study, 19 beer samples were analyzed. Parameters such as pH, Total Acidity, Reducing Sugar Content and TPC were evaluated. For the determination of antioxidant activity, DPPH scavenging activity and metal chelating activity (MCA) were analyzed in all samples. Craft beers demonstrated a high phenolic content (ranging from 343.78 mg GAE/L to 2172.49 mg GAE/L), significantly different from industrial beers. Craft beers demonstrated a higher inhibition of DPPH radicals and higher MCA than the raw materials. DPPH inhibition ranged from 36.5% to 96.0% for malt and 64.7% to 79.6% in hops samples. MCA also varied between the different samples, with results of 12.0% to 24.8% in malt samples and 3.8% to 23.5% in hops. Raw materials can potentially influence the antioxidant activity of the resulting beer. Positive correlations between TPC and physicochemical properties can be useful to help consumers choose beers with added value for health.
- Plantas africanas com atividade citotóxicaPublication . Santos, Roberta; Veiga, Inês; Cruz, Agostinho; Ferraz Oliveira, Rita; Pinho, Cláudia; Oliveira, Ana IsabelO cancro é a segunda causa de morte, globalmente, atingindo uma em cada seis pessoas, em 2018. Os tipos de cancros mais prevalentes são o cancro da mama, próstata, colorretal, pulmão, colo do útero e estômago. O continente africano possui um amplo património de plantas, muitas ainda por explorar, e outras que têm demonstrado atividades diversas como, antioxidante, anti-inflamatória, antimicrobiana e/ou anticancerígena. Além disso, muitos pacientes apenas têm acesso a medicina tradicional o que inclui o uso de plantas medicinais, face a problemas económicos. Desta forma, a procura de evidências acerca das plantas com potencial atividade anticancerígena é importante. Compilar informação sobre atividade anticancerígena de plantas existentes no continente africano.
- Proceedings of Research and Practice in Allied and Environmental Health 2023 - XVIII Colóquio de Farmácia: Papel da Farmácia em OncologiaPublication . Pinho, Cláudia; Cruz, Agostinho; Oliveira, Ana Isabel; Jesus, Ângelo; Moreira, Fernando; Santos, Marlene; Correia, Patrícia; Ferraz Oliveira, RitaO evento, que conta já com a sua 18ª edição, foi um espaço privilegiado para partilhar, evidenciar e debater o que se investiga e faz em áreas prioritárias e desafiantes da Farmácia, como a Oncologia no contexto de Farmácia Comunitária e Hospitalar. Pretendeu, ainda, ser um momento de troca de opiniões e de experiências entre os participantes, académicos, investigadores e profissionais.