ESS - APCT - Comunicações em eventos científicos
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Browsing ESS - APCT - Comunicações em eventos científicos by Subject "Breast cancer"
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- Digital pathology in the immunohistochemical evaluation of biomarkers in breast cancerPublication . Lopes, J.; Silva, S.; Monteiro, J.; Pinto, I.M.; Silva, ReginaCurrently, the evaluation of biomarkers HER-2 and ER is critical for targeting therapy for breast cancer and is performed by experienced pathologists, which takes time and causes a certain interobserver variability. The use of histological slide scanners coupled with the application of software for immunoexpression quantification can be profitable in pathological laboratories routine. This study aims to compare the quantification of HER-2 and ER immunoexpression employing automatic algorithms, using as standard the evaluation performed by a pathologist.
- Molecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell linesPublication . Quintela Vieira, Ana Filipa; Marques-Magalhães, Ângela; Miranda-Gonçalves, Vera; Ferraz, Ricardo; Prudêncio, Cristina; Jerónimo, Carmen; Silva, ReginaProstate Cancer (PCa) and Breast Cancer (BCa) are the leading causes of cancer morbidity and mortality, worldwide, when diagnosed in advanced stages of the disease. Currently available therapies have limited curative effect, leading to the progression to highly aggressive hormone-resistant phenotypes. Thus, the development of new anti-tumor agents becomes imperative. Ionic liquids are organic salts with anti-neoplastic activity and have been studied in the pharmaceutical industry. Previous work of our team demonstrated that the ionic liquid [C16Pyr][Amp] has significant anti-tumor properties in PCa and BCa cell lines. However, the main cellular pathways affected were not characterized. Therefore, the aim of this work was to explore the molecular impact of [C16Pyr][Amp] treatment in order to identify relevant genes that have altered expression upon treatment and that can justify the anti-cancer effect observed in the in vitro assays.
- Natural and synthetic compounds as anti-cancer therapies for breast and prostate cancerPublication . Magalhães, Ângela; Vieira, Filipa Quintela; Ferraz, Ricardo; Pinho, Cláudia; Vieira, Mónica; Oliveira, Ana; Prudêncio, Cristina; Cruz, Agostinho; Jerónimo, Carmen; Silva, ReginaBreast Cancer (BCa) and Prostate Cancer (PCa) are the most prevalent tumors in females and males, respectively, being the main causes of cancer morbidity and mortality, worldwide. Currently, there is no available curative treatment for the hormone-resistant tumors, being the development of new therapeutic strategies using innovative anticancer agents imperative. Thus, the main goal of this work was to evaluate the anticancer properties of natural and synthetic compounds through in vitro assays.
- Novel natural and synthetic compounds for treating hormone resistant tumorsPublication . Silva, ReginaCancer is a leading cause of mortality worldwide. Despite significant advances in medical research, deaths due to cancer are continuously increase. Data from 2010 has shown the colorectal, breast, prostate and lung cancer as the most common in Portugal. Considering the North Region, prostate cancer and breast cancer are the most incident in men and women, respectively. Despite all the improvement in cancer early detection and treatment, the high mortality rates challenges the discovery of new anticancer agents. In the last years, several team members were involved in the study of the bioactive potential of natural and synthetic compounds at the Health and Environment Research Centre at School of Health of the Polytechnic Institute of Porto (CISA ESS—P.Porto). From previous works, extracts isolated from plants and synthetic compounds, such as ionic liquids and quinoxalines, revealed an interesting bioactive potential as cancer drug. Following these previous approaches and considering the background of the team members in cancer research, the main goal of this project is to infer about the potential of these natural and synthetic compounds as anti-cancer drugs to common North Portugal cancer hormone-resistant tumors, namely castration-resistant prostate tumors and estrogen-independent breast tumors.