Browsing by Author "Zeevart, Jan"
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- 188Re-PEI-MP as potential agent for metabolic radiotherapyPublication . Ferreira, Sara; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene D.; Botelho, Maria FilomenaIntroduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of watersoluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for osteosarcoma, through in vitro and in vivo models.
- An in vivo evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Pires, Salomé; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria Filomena188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for bladder carcinoma
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of osteosarcoma and bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Brito, Ana; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy.
- Análise do Potencial do 188Re-PEI-MP como Agente para Radioterapia Metabólica na Terapia de OsteossarcomaPublication . Ferreira, Sara; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntrodução e Objectivos: O desenvolvimento do polímero PEI-MP (polietilenoimina funcionalizada com grupos metilfosfonato), possível de radiomarcar com o 188Re (emissor de partículas beta de alta energia), parece poder ter um forte potencial para o tratamento de osteossarcoma. O objectivo deste estudo residiu na avaliação da eficácia do 188Re-PEI-MP como agente terapêutico para o tratamento de osteossarcoma.
- A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).
- Evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
- A New Possible Approach for Therapy and Follow Up of Bladder CancerPublication . Ferreira, Sara; Abrantes, Ana Margarida; Brito, Ana; Laranjo, Mafalda; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labelled with 188Re and 99mTc, have a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its follow up.
- A Possible New Molecule For Diagnosis and Follow Uo of Bladder Cancer: The Radiolabelled Polymer 99mTc-PEI-MPPublication . Tavares-Silva, Edgar; Ferreira, Sara; Abrantes, Ana Margarida; Brito, Ana; Laranjo, Mafalda; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling. However, in biodistribution studies performed with this polymer radiolabelled with different radionuclides, was obvious a higher uptake by the bladder wall, that might demonstrate a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of PEI-MP radiolabeled with 99mTc for imaging diagnosis and follow up of bladder cancer.
- O potencial do 188Re-PEI-MP para a radioterapia metabólica de osteossarcoma e carcinoma da bexigaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntrodução e Objectivos: O polímero PEI-MP, polietilenoimina funcionalizada com grupos metilfosfonato, marcado com o 188Re tem um forte potencial para a radioterapia metabólica. Este estudo teve por objectivo avaliar a eficácia do 188Re-PEI-MP como agente terapêutico para osteossarcoma e carcinoma da bexiga.