An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of bladder carcinoma

Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria Filomena

http://hdl.handle.net/10400.22/6431

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Authors

Ferreira, Sara

Laranjo, Mafalda

Abrantes, Ana Margarida

Botelho, Maria Filomena

Abstract(s)

188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for bladder carcinoma