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Introduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling. However, in biodistribution studies performed with this polymer radiolabelled with different radionuclides, was obvious a higher uptake by the bladder wall, that might demonstrate a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of PEI-MP radiolabeled with 99mTc for imaging diagnosis and follow up of bladder cancer.