Browsing by Author "Metello, Luís"
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- Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its ApplicationsPublication . Costa, Pedro; Metello, Luís; Alves, Francisco; Naia, M. DuartePositron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18F, 11C, and, more recently, 68Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β+ endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging
- Modern and Efficient Management in the Nuclear Medicine Department: the Lean ApproachPublication . Metello, Luís; Rocha, Francisca; Roda, Ana; Capoulas, Miriam; Rodrigues, Adriano; Nunes, Amália; Macedo, Rafael; Cunha, LídiaThere is a worldwide concern in the healthcare systems for increased efficiency. Efficient management tools are thus required to deal with the increased complexity and quality-driven processes characteristics of healthcare. One of them is “Lean Management”, known for adding value to a variety of industries.
- Nuclear medicine technologists' education and training: Where are we…and where do we intend to go?Publication . Metello, Luís; Vieira, Domingos; Ferreira, Sara; Lemos, Joana; Costa, Pedro; Cunha, LídiaThis work aims to promote Critical Thinking and to sustain discussion about distinct methods and options for Education and Training of Nuclear Medicine Technologists.
- PET imaging using titanium-45: Could it be useful?Publication . Costa, Pedro; Metello, Luís; Alves, F.; Naia, M. DuarteIn the last decade a wider application of positron emission tomography (PET) as one of the most powerful medical imaging technologies was observed. This was largely due to the increased availability of equipment dedicated to production of radioisotopes, mainly due to the installation of low energy cyclotrons in hospitals, research institutes and pharmaceutical industries specialized in radiopharmaceutical production.
- Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated ProgenyPublication . Lemos, Joana; Neuparth, T.; Trigo, M.; Costa, Pedro; Vieira, Domingos; Cunha, L.; Ponte, F.; Costa, P. S.; Metello, Luís; Carvalho, A. P.This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.
- The acute effect on three-dimensional cellular proliferation rate of low dose irradiation exposuresPublication . Costa, Pedro; Lemos, Joana; Cunha, Lídia; Neuparth, Teresa; Genésio, Paula; Ponte, Fernanda; Costa, Paulo; Crespo, Paulo; Metello, LuísLow doses of ionizing radiation are not yet consistently studied and documented. In such context, more advanced and complex biological models should be applied to obtain relevant data. Known limitations of monolayer cellular models and ever increasing difficulties to use some biological models, lead to develop advanced biological models, namely three-dimensional cell cultures.