Browsing by Author "Ferreira, Sara"
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- 188Re-PEI-MP as potential agent for metabolic radiotherapyPublication . Ferreira, Sara; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene D.; Botelho, Maria FilomenaIntroduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of watersoluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for osteosarcoma, through in vitro and in vivo models.
- Actual Trends in Nuclear MedicinePublication . Vieira, Domingos; Lemos, Joana; Ferreira, Sara; Metello, Luís F.
- An in vivo evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Pires, Salomé; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria Filomena188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for bladder carcinoma
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of osteosarcoma and bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Brito, Ana; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy.
- Análise do Potencial do 188Re-PEI-MP como Agente para Radioterapia Metabólica na Terapia de OsteossarcomaPublication . Ferreira, Sara; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntrodução e Objectivos: O desenvolvimento do polímero PEI-MP (polietilenoimina funcionalizada com grupos metilfosfonato), possível de radiomarcar com o 188Re (emissor de partículas beta de alta energia), parece poder ter um forte potencial para o tratamento de osteossarcoma. O objectivo deste estudo residiu na avaliação da eficácia do 188Re-PEI-MP como agente terapêutico para o tratamento de osteossarcoma.
- Analysing the usefulness of motion correction software in myocardial perfusion imagingPublication . Cunha, Lídia; Lamego, Juliana; Ferreira, Sara; Lemos, Joana; Vieira, Domingos; Metello, Luís F.Introduction Myocardial Perfusion Imaging (MPI) is a very important tool in the assessment of Coronary Artery Disease ( CAD ) patient s and worldwide data demonstrate an increasingly wider use and clinical acceptance. Nevertheless, it is a complex process and it is quite vulnerable concerning the amount and type of possible artefacts, some of them affecting seriously the overall quality and the clinical utility of the obtained data. One of the most in convenient artefacts , but relatively frequent ( 20% of the cases ) , is relate d with patient motion during image acquisition . Mostly, in those situations, specific data is evaluated and a decisi on is made between A) accept the results as they are , consider ing that t he “noise” so introduced does not affect too seriously the final clinical information, or B) to repeat the acquisition process . Another possib ility could be to use the “ Motion Correcti on Software” provided within the software package included in any actual gamma camera. The aim of this study is to compare the quality of the final images , obtained after the application of motion correction software and after the repetition of image acqui sition. Material and Methods Thirty cases of MPI affected by Motion Artefacts and repeated , were used. A group of three, independent (blinded for the differences of origin) expert Nuclear Medicine Clinicians had been invited to evaluate the 30 sets of thre e images - one set for each patient - being ( A) original image , motion uncorrected , (B) original image, motion corrected, and (C) second acquisition image, without motion . The results so obtained were statistically analysed . Results and Conclusion Results obtained demonstrate that the use of the Motion Correction Software is useful essentiall y if the amplitude of movement is not too important (with this specific quantification found hard to define precisely , due to discrepancies between clinicians and other factors , namely between one to another brand); when that is not the case and the amplitude of movement is too important , the n the percentage of agreement between clinicians is much higher and the repetition of the examination is unanimously considered ind ispensable.
- A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).
- Estudo do valor da hidratação na qualidade de imagem de uma cintigrafia ósseaPublication . Ferreira, Sara; Silva, José Alexandre; Amorim, Inês; Castro, Rosa; Nery, Jorge; Oliveira, Marta; Sousa, Maria; Cunha, Lídia; Metello, Luís F.A cintigrafia óssea é um método de diagnóstico não invasivo e sensível em detectar lesões ósseas precocemente. Um dos importantes aspectos técnicos a considerar quando se trata da preparação do doente é o nível de hidratação. O objectivo deste estudo centra-se sobre a apreciação do valor de hidratação na qualidade das imagens de uma cintigrafia óssea
- Evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
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