Browsing by Author "Brito, Ana"
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- An in vivo evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Pires, Salomé; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria Filomena188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for bladder carcinoma
- An in vivo study to analyse the potential of 188Re-PEI-MP for metabolic radiotherapy of osteosarcoma and bladder carcinomaPublication . Ferreira, Sara; Laranjo, Mafalda; Brito, Ana; Abrantes, Ana Margarida; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re are recent approaches, with a strong potential for metabolic radiotherapy.
- A comparative study to analyse the potential of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP for therapy of bladder carcinoma and osteosarcomaPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The water-soluble polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits high energy B- particles) and 99mTc presents a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate in vivo the potential of 188Re-PEI-MP as therapeutic agent and 99mTc-PEI-MP asdiagnostic agent for bladder carcinoma and osteosarcoma. Material and methods: Cytotoxicity of PEI-MP was investigated in bladder carcinoma cell line (CRL-1472) using the MTT test for different concentrations of PEI-MP (1 uM to 1000 uM) and incubation times (24h, 48h, 72h and 96h).
- Evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow upPublication . Ferreira, Sara; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaThe development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.
- Língua Gestual Portuguesa e outras Línguas de Sinais Estudos LinguísticosPublication . Morgado, Celda (Choupina, Celda); Brito, AnaEste livro abrange temas de áreas já mais estudadas das línguas gestuais e em particular da Língua Gestual Portuguesa (LGP) – o léxico e a fonologia –, mas inclui também áreas menos exploradas, como a sintaxe e a semântica, além do domínio mais vasto da variação e da mudança. Enquanto o léxico das línguas gestuais está muito estudado em diferentes perspetivas, há muitas dimensões semânticas destas línguas ainda por analisar e compreender. Uma dessas dimensões é a quantificação. Os estudos sobre quantificação em línguas gestuais são raros e há questões difíceis de responder: como é que em diferentes línguas gestuais se exprime a quantificação universal (todos os x) e a quantificação existencial (alguns x)? Como é que estas línguas exprimem a definitude e a indefinitude? Uma das questões centrais a explorar nas línguas gestuais é a organização das frases simples, nos seus diferentes tipos, e a organização das frases complexas, incluindo a ordem de palavras e a maneira como estas línguas exprimem a estrutura argumental dos verbos, problemas típicos abordados em sintaxe. Neste livro, vários textos analisam estes temas, embora de maneiras muito distintas. O livro agora editado contém uma seleção de textos sobre Morfossintaxe da LGP e de outras línguas de sinais, organizado pelo Centro de Linguística da Universidade do Porto (CLUP) e pelo Centro de Investigação e Inovação em Educação (inED) da Escola Superior de Educação do Politécnico do Porto (ESE/IPP), sendo já a quinta publicação conunta.
- A New Possible Approach for Therapy and Follow Up of Bladder CancerPublication . Ferreira, Sara; Abrantes, Ana Margarida; Brito, Ana; Laranjo, Mafalda; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labelled with 188Re and 99mTc, have a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its follow up.
- A Possible New Molecule For Diagnosis and Follow Uo of Bladder Cancer: The Radiolabelled Polymer 99mTc-PEI-MPPublication . Tavares-Silva, Edgar; Ferreira, Sara; Abrantes, Ana Margarida; Brito, Ana; Laranjo, Mafalda; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling. However, in biodistribution studies performed with this polymer radiolabelled with different radionuclides, was obvious a higher uptake by the bladder wall, that might demonstrate a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of PEI-MP radiolabeled with 99mTc for imaging diagnosis and follow up of bladder cancer.
- Radiolabeled polyethyleneiminomethyl phosphonic acid as a molecule with potential for diagnosis and therapy. Comparative study on models of bladder cancer and osteossarcoma.Publication . Ferreira, Sara; Abrantes, Ana Margarida; Brito, Ana; Laranjo, Mafalda; Metello, Luís F.; Zeevart, Jan; Louw, Werner; Dormehl, Irene; Botelho, Maria FilomenaIntroduction: The polymer PEI-MP (polyethyleneiminomethyl phosphonic acid) that might be labeled with 99mTc and 188Re, have a strong potential for diagnosis and metabolic radiotherapy, respectively. The aim of this study was to evaluate the efficacy of 99mTc-PEI-MP for diagnosis and 188Re-PEI-MP as therapeutic agent, in a comparative study using in vitro and in vivo models of bladder cancer and osteossarcoma
- The influence of anxiety, hostility and type D personality on health behaviors of university studentsPublication . Dores, Artemisa Rocha; Barros, Débora; Brito, Ana; Singh, Suveer; Teixeira, RicardoInterest in type D personality and negative emotions such as anxiety and hostility has been growing. These factors are associated with health risk behaviors, which could determine the incidence and progression of cardiovascular disease in initially healthy individuals. We sought to evaluate the prevalence of anxiety, hostility and type D personality and its influence on health risk behaviors in a cohort of university students. One hundred and fifty-one students completed five questionnaires. Mixed methodology using Pearson’s correlation, and regression analysis determined associations between risk factors and health behaviors. We observed a mild hostility and anxiety disturbance (M=0.95; SD=0.61 and M=0.91; SD=0.70). Type D personality was present in 37.7% of the participants. There was a positive association between hostility and smoking (r=0.168; p=0.04), alcohol (r=0.215; p=0.008) and coffee consumption (r=0.280; p=0.000), as well as a negative association between hostility and anxiety (r=-0.263; p=0.001), type D personality (r=-0.194; p=0.017) and lifestyle (r=-0.306; p=0.000). Besides gender variables, alcohol consumption, coffee intake, physical exercise, diet and type D personality assumed statistical relevance explaining the health behaviors (p<0.05). Based on these results we argue that college students may benefit from a premature evaluation for the prevention of future cardiovascular disease.