ESS - CQB - Posters apresentados em eventos científicos
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Browsing ESS - CQB - Posters apresentados em eventos científicos by Author "Almeida, Joana"
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- Biotechnology and biochemistry laboratorial education through the SARS-CoV2 pandemic: challenges, truths and takeawaysPublication . Almeida, Joana; Pereira, Cassilda; Coelho, Pedro; Teixeira, Dulce; Louçano, Marta; Bento, C.; Cerqueira, Maria João; Prudêncio, Cristina; Ferraz, Ricardo; Vieira, MónicaIn early 2020, the COVID-19 pandemic forced the higher education institutions to adapt to a new form of teaching and learning, from presential to full remote, blended and hybrid environment.
- Obesity and brain cancer: proteomic analyzes of the influence of the adipocyte secretome on glioma Gl261 cellsPublication . Fernandes, Rúben; Costa, J.; Almeida, Joana; Coelho, Pedro; Cea, V.; Galésio, M.; Diniz, MS.; Prudêncio, Cristina; Sala, C.Glioma is the most frequent form of malignant brain tumor in the adults and childhood. There is a global tendency toward a higher incidence of gliomas in highly developed and industrialized countries. Simultaneously obesity is reaching epidemic proportions in such developed countries. It has been highly accepted that obesity may play an important role in the biology of several types of cancer. We have developed an in vitro method for the understanding of the influence of obesity on glioma mouse cells (Gl261).
- Reóstato dos esfingolípidos: análise lipidómica de ceramidas e esfingosina-1-fosfato num modelo animal de obesidadePublication . Fernandes, Rúben; Almeida, Joana; Coelho, Pedro; Prudêncio, Cristina; Soares, RaquelO tecido adiposo é um órgão endócrino e dinâmico que secreta importantes factores para o sangue, regula o metabolismo, a função imune, o fluxo vascular e linfático, entre muitas outras. Em caso de acumulação de tecido adiposo, devido a uma dieta rica em gordura ou disfunção metabólica, os adipócitos podem desencadear uma reação inflamatória, sendo que a expressão de adipocinas varia de acordo com a distribuição de tecido adiposo subcutâneo e visceral. Os esfingolípidos constituem uma classe importante de compostos bioactivos. Lípidos como as ceramidas (Cer) esfingosinas e esfingosinas-1-fosfato (S1P) são importantes na sinalização molecular dentro e for a das células e, desempenhando assim um papel essencial na regulação de eventos celulares como o crescimento celular, diferenciação, respostas ao stress e apoptose. Alguns estudos indicam que as S1P promovem a proliferação celular enquanto que as Cer promovem a apoptose.
- The influence of phytochemicals on grade IV prostate adenocarcinomaPublication . Casal, Ana Carolina; Almeida, JoanaAdenocarcinoma is a worldwide concern, being one of the main causes of death in men. Bone metastases derived from this type of cancer, the fact that tumor cells are increasingly resistant to existing oncological drugs and the side effects caused by these are the main causes for the need to develop new therapies. Thus, silymarin and cinnamic acid (CINN) are examples of two phytochemicals that have been studied for the treatment of this pathology, since they have a fundamental role in chemoprevention, that is, they prevent stages of initiation, promotion and progression, associated with carcinogenesis, reducing cancer morbidity and mortality. The main objective of this project is to evaluate the effect of both phytochemicals on the PC3 cell line of grade IV prostatic adenocarcinoma. Thus, parameters such as viability (MTT) and cell motility (injury) were evaluated through the application of different concentrations of compounds in tumor cells. It was demonstrated, with the results obtained, that both silymarin and CINN have the ability to decrease the viability and motility of prostate cancer cells. In short, it is possible to state that the phytochemicals in question have an antitumor effect, proving their potential as treatments against the PC3 cell line, through the reduction of cell proliferation and induction of apoptosis.