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ESS - FAR - Livro, parte de livro ou capítulo de livro

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http://hdl.handle.net/10400.22/1050

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Percorrer ESS - FAR - Livro, parte de livro ou capítulo de livro por autor "Carvalho, Daniel"

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  • Optimization of an HPLC-DAD method for Quercetin detection
    Publication . Carvalho, Daniel; Moreira, Fernando; Oliveira, Ana Isabel
    High-performance liquid chromatography (HPLC) is one of the most used liquid chromatographic techniques owing to its versatility that allows an optimal resolution. Quercetin (QUE), a polyphenol, has received increasing attention due to its antioxidant properties. Efforts have been made to overcome the traditional poor oral bioavailability of quercetin, requiring the development of analytical techniques for quercetin detection in different matrices. The main objective of this work was the optimization of a HPLC-Diode Array Detector (DAD) method for quercetin. An optimization process was conducted to guarantee the best conditions and results. Detection and quantification were executed with a reverse phase C-18 column. Different mobile phase (MP) compositions, flow rates, and wavelengths (with DAD) were studied. Better results were achieved with a MP composition of water:acetonitrile:methanol (55:40:5), with 1.5% acetic acid at a 1.3 mL/minute flow rate, with good results regarding chromatogram resolution, and quercetin quantification and detection.
    2023-09-13Capítulo de livro Acesso aberto Ver mais
  • Potential drug interactions between oral antineoplastic agents and opioid analgesics
    Publication . Antunes, Cláudia; Carvalho, Daniel; Jesus, Ângelo
    Oral antineoplastic drugs use has been gaining more importance due to its multiple benefits and the introduction of new molecules with new mechanisms of action. Opioids are often conjugated with antineoplastic therapy, however, this association brings possible drug interactions. Cytochrome P450 is responsible for the metabolization of a great part of drugs on the market. Identifying, explaining, and assessing the severity of possible drug interactions between oral antineoplastic agents and opioid analgesics were the aims of this investigation. A cross-sectional observational study was developed. Drugs selected in FHNM, were combined one by one in the Micromedex database. Twenty-three interactions were found with different types of grades of evidence and severity, and six were explained. Procarbazine was the oral antineoplastic with the highest number of possible interactions, while the opioid was buprenorphine. It’s important to monitor drug interactions in cancer patients considering the serious consequences that may arise from these.
    2022-11Capítulo de livro Acesso aberto Ver mais