ESS - MN - Posters apresentados em eventos científicos
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Percorrer ESS - MN - Posters apresentados em eventos científicos por autor "Alves, Francisco"
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- Application of Monte Carlo simulation codes to plan an activation experiment in Scandium-45 targetsPublication . Costa, Pedro; Metello, Luís F.; Alves, Francisco; Naia, M. DuarteData characterizing excitation functions of nuclear reactions are necessary for different applications, with the process of radionuclide production being assumed as a relevant example. This is the only way to define and optimize technical parameters involved in such a process. However, nuclear activation experimental studies are sometimes difficult to implement, and care should be taken before its execution, in order to obtain all relevant data, while correctly planning the experiences. In this context, Monte Carlo simulation tools are widely applied to overtake such difficulties. This work describes a case-study aiming to characterize nuclear reactions excitation functions induced by a proton beam and its interaction with a Scandium target – a specific situation that is not yet completely characterized and that might be of relevance, since it could be useful to produce medically relevant radionuclides (eg. Titanium-45).
- Cyclotron produced 45Ti-Titanium: why & how… so WHY NOT?Publication . Costa, Pedro; Metello, Luís F.; Cunha, Lídia; Johnson, Richard R.; Mattei, Lidia; Gelbart, W.; Obermair, J.; Dietl, B.; Nauschnig, R.; Artner, Christoph; Lass, Piotr; Currie, Geoff; Carmo, Sérgio; Alves, Francisco; Naia, M. DuarteThere are many different radioisotopes well known and characterized for medical use, with almost all of them able to be artificially produced. Nevertheless, routine clinical applications of PET imaging are still based on 18F, in excess of 97% of the cases, with 11C, 13N and 68Ga sharing the few remaining situations. This trend could change in the – hopingly near – future, since several groups worldwide are busy developing very promising new processes using less conventional radionuclides, aiming to contribute for spreading the use and efficacy of clinical diagnostic using Nuclear Medicine imaging techniques, evolving more and more in the direction of personalized medicine, an worldwide growing societal request. Our group is busy studying 45Ti, interested by its many interesting properties and assuming it as a high-potential candidate: in fact 45Ti presents a physical half-life of 3.09h (50% higher than 18F) together with relevant chemical properties, that enable radiolabelling with bifunctional chelates, ligands or even to radiolabel titanium (di)oxide nanoparticles. Considering that data characterizing excitation functions are mandatory for radionuclide optimal production, the present work refers to our results regarding the 45Sc(p,n)45Ti nuclear reaction, being studied as a potential route to efficiently produce 45Ti in low energy cyclotrons.
- The use of radiolabeled nanoparticles for biomedical imagingPublication . Costa, Pedro; Metello, Luís F.; Alves, Francisco; Naia, M. DuarteIntroduction: In the last years, the practice of medicine is being changing with a special emphasis on the application of technological innovations where medical imaging modalities play an important role. Between several imaging modalities, Molecular Imaging (that is essentially based on Nuclear Medicine) is one of the most interesting solutions. On the other hand, assuming that nanoparticles are being studied as drug delivery systems, its application as vectors for radionuclide-based imaging is in a clear growing.