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Advisor(s)
Abstract(s)
There are many different radioisotopes well known and characterized for
medical use, with almost all of them able to be artificially produced. Nevertheless, routine
clinical applications of PET imaging are still based on 18F, in excess of 97% of the cases, with
11C, 13N and 68Ga sharing the few remaining situations. This trend could change in the –
hopingly near – future, since several groups worldwide are busy developing very promising
new processes using less conventional radionuclides, aiming to contribute for spreading the
use and efficacy of clinical diagnostic using Nuclear Medicine imaging techniques, evolving
more and more in the direction of personalized medicine, an worldwide growing societal
request. Our group is busy studying 45Ti, interested by its many interesting properties and
assuming it as a high-potential candidate: in fact 45Ti presents a physical half-life of 3.09h (50%
higher than 18F) together with relevant chemical properties, that enable radiolabelling with
bifunctional chelates, ligands or even to radiolabel titanium (di)oxide nanoparticles.
Considering that data characterizing excitation functions are mandatory for radionuclide
optimal production, the present work refers to our results regarding the 45Sc(p,n)45Ti nuclear
reaction, being studied as a potential route to efficiently produce 45Ti in low energy cyclotrons.