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Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens

2018Journal article Open access
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dc.contributor.authorGomes, Ana
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorFicker, Lauren
dc.contributor.authorCollins, Margaret S.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorCushion, Melanie T.
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2019-07-01T12:42:42Z
dc.date.available2019-07-01T12:42:42Z
dc.date.issued2018
dc.description.abstractThe impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Ferraz, R., Ficker, L., Collins, M. S., Prudêncio, C., Cushion, M. T., Teixeira, C., & Gomes, P. (2018). Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy, 62(11), 10.1128/aac.00983-18. https://doi.org/10.1128/aac.00983-18
dc.identifier.doi10.1128/AAC.00983-18pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Microbiologypt_PT
dc.relationNorte-01-0145-FEDER-000024pt_PT
dc.relationPiling - Peptide-base lonic Luiquids towards heaLING of diabetic foot ulcer infections
dc.relation.publisherversionhttps://aac.asm.org/content/62/11/e00983-18.longpt_PT
dc.subjectPneumocystispt_PT
dc.subjectchloroquinept_PT
dc.subjectImmunosuppressedpt_PT
dc.subjectLung infectionpt_PT
dc.subjectMalariapt_PT
dc.subjectPneumoniapt_PT
dc.titleChloroquine Analogues as Leads against Pneumocystis Lung Pathogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePiling - Peptide-base lonic Luiquids towards heaLING of diabetic foot ulcer infections
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F135073%2F2017/PT
oaire.citation.issue11pt_PT
oaire.citation.titleAntimicrobial Agents and Chemotherapypt_PT
oaire.citation.volume62pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_NORTE
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscovery881a8ad5-ab13-4e49-89f4-08ca61cc81e3
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