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Orientador(es)
Resumo(s)
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
Descrição
Palavras-chave
Pneumocystis chloroquine Immunosuppressed Lung infection Malaria Pneumonia
Contexto Educativo
Citação
Gomes, A., Ferraz, R., Ficker, L., Collins, M. S., Prudêncio, C., Cushion, M. T., Teixeira, C., & Gomes, P. (2018). Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy, 62(11), 10.1128/aac.00983-18. https://doi.org/10.1128/aac.00983-18
Editora
American Society for Microbiology