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Tablet splitting: influence of technique and tablet format

2022-11Book part Open access
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dc.contributor.authorAlexandre, Ana
dc.contributor.authorFerreira, Sónia
dc.contributor.authorJesus, Ângelo
dc.date.accessioned2022-12-06T12:17:54Z
dc.date.available2022-12-06T12:17:54Z
dc.date.issued2022-11
dc.description.abstractTablet splitting is a commonly used technique to obtain half of the dose or to facilitate tablet intake. However, there is a risk of not obtaining the correct dose and the efficacy depends on factors such as splitting method and tablet characteristics. Objective: To assess significant differences regarding tablet format or splitting method, regarding loss of mass and splitting accuracy. Methods: Volunteers split ten formulations by hand or using a kitchen knife. Results were treated in order to verify compliance with European Pharmacopeia standards for tablet splitting and recommendations on loss of mass. SPSS was used to assess significant differences between the two methods and tablet format when analysing loss of mass or splitting accuracy. Results: Of the twenty formulation/method combinations, only five complied with all the criteria. There was a significant difference regarding methods and loss of mass, with splitting by hand being the one to achieve the best results. Oblong tablets scored significantly better regarding loss of mass and splitting accuracy. Conclusion: Results seem to indicate that best results can be achieved when splitting tablets if using oblong tablets and splitting them by hand.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlexandre, Ana, Ferreira, Sónia, & Jesus, Ângelo. (2022). Tablet splitting: Influence of technique and tablet format. Em ATHENA Research Book, Volume 1 (Vol. 1, pp. 303–311). ATHENA European University, University of Maribor Press.pt_PT
dc.identifier.doi10.18690/um.3.2022pt_PT
dc.identifier.isbn978-961-286-659-4
dc.identifier.isbn978-961-286-658-7
dc.identifier.urihttp://hdl.handle.net/10400.22/21149
dc.language.isoengpt_PT
dc.publisherATHENA European University & University of Maribor Presspt_PT
dc.relation.publisherversionhttps://press.um.si/index.php/ump/catalog/book/735pt_PT
dc.subjectDrug compounding/methodspt_PT
dc.subjectTabletspt_PT
dc.subjectTablet splittingpt_PT
dc.subjectTablet characteristicspt_PT
dc.subjectTablet formatpt_PT
dc.titleTablet splitting: influence of technique and tablet formatpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage311pt_PT
oaire.citation.startPage303pt_PT
oaire.citation.titleATHENA Research Book, Volume 1pt_PT
oaire.citation.volume1pt_PT
person.familyNameJesus
person.givenNameÂngelo
person.identifier.ciencia-idA91F-3585-4F42
person.identifier.orcid0000-0003-3972-8253
person.identifier.ridA-4404-2012
person.identifier.scopus-author-id56153841300
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication1cbff3da-9800-4bd7-8d84-fd8d9ca819b2
relation.isAuthorOfPublication.latestForDiscovery1cbff3da-9800-4bd7-8d84-fd8d9ca819b2

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