Publication
MicroRNAs biomarkers for early screening of colorectal cancer
| dc.contributor.author | Santos, Daniela | |
| dc.contributor.author | Gaiteiro, Cristiana | |
| dc.contributor.author | Santos, Marlene | |
| dc.contributor.author | Santos, Lúcio | |
| dc.contributor.author | Dinis-Ribeiro, Mário | |
| dc.contributor.author | Lima, Luís | |
| dc.date.accessioned | 2023-09-21T16:45:30Z | |
| dc.date.available | 2023-09-21T16:45:30Z | |
| dc.date.issued | 2023-07-11 | |
| dc.description.abstract | Colorectal cancer (CRC) is the most incident neoplasia in Portugal. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (miRs) play a role in genetic events associated with carcinogenesis, and their disrupted expression in tumors can be readily detected in biological fluids [5-8]. This characteristic offers a promising tool for CRC screening. Review the existing literature to assess the advancements made in recent years in the potential use of miRs as a biomarker to improve the CRC screening. A comprehensive literature review was conducted, analyzing a total of 54 studies that investigated miRs expression in stool and blood samples and evaluated is potential as biomarkers for CRC identification. In our search, we identified a total of 104 miRs with potential relevance to CRC screening in both stool and blood samples. Among these miRs, miR-21-5p and miR-92a-3p, along their cluster including miR-29a-3p, miR-20a-5p, and miR-18-5p, emerged as the most frequently mentioned and promising candidates. Furthermore, is reported a differential expression of miR-135b-5p, miR-223-3p, and miR-451 only in stool specimens, while miR-139-3p and miR-4516 exhibit this altered expression in blood samples. Other notable miRs, including miR-146a-5p, miR-199a-5p, miR-421, miR-27a-3p, and miR-221-3p, have shown promising results in detecting advanced adenomas, exhibiting a better performance compared to FIT. However, these findings require further validation in a larger patient cohort and across different biological samples to confirm their significance for CRC and precancerous lesions detection. Therefore, miRs are regarded as a promising approach for enhancing the detection of CRC, particularly in the identification of precancerous lesions. Nevertheless, further studies are required to assess the accuracy of these molecules as biomarkers. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Santos, D., Gaiteiro, C., Santos, M., Santos, L., Dinis-Ribeiro, M., & Lima, L. (2023). MicroRNAs Biomarkers for Early Screening of Colorectal Cancer. Proceedings of Research and Practice in Allied and Environmental Health, 1(1), 17. https://doi.org/10.26537/prpaeh.v1i1.5142 | pt_PT |
| dc.identifier.doi | 10.26537/prpaeh.v1i1.5142 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/23592 | |
| dc.language.iso | eng | pt_PT |
| dc.relation.publisherversion | https://parc.ipp.pt/index.php/PRPAEH/article/view/5142 | pt_PT |
| dc.subject | Biomarkers | pt_PT |
| dc.subject | Colorectal cancer | pt_PT |
| dc.subject | Early screening | pt_PT |
| dc.subject | MicroRNAs | pt_PT |
| dc.title | MicroRNAs biomarkers for early screening of colorectal cancer | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 17 | pt_PT |
| oaire.citation.title | Proceedings of Research and Practice in Allied and Environmental Health 2023 | pt_PT |
| oaire.citation.volume | 1 (1) | pt_PT |
| person.familyName | Santos | |
| person.givenName | Marlene | |
| person.identifier | 1508370 | |
| person.identifier.ciencia-id | 8311-B967-31C4 | |
| person.identifier.orcid | 0000-0001-5020-5942 | |
| person.identifier.scopus-author-id | 57110502000 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isAuthorOfPublication | 8ce9ee39-a4c6-46ae-99e2-49397b550f1b | |
| relation.isAuthorOfPublication.latestForDiscovery | 8ce9ee39-a4c6-46ae-99e2-49397b550f1b |