Generation of an obese diabetic mouse model upon conditional Atrx disruption

ATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homozygous mice (P.AtrxHOM) exhibited obesity, diabetes, glucose intolerance, and pancreatic adiposity at a higher extent than age- and sex-matched controls (P.AtrxWT).

Keywords

Atrx Conditional mouse model Endocrine dysfunction Fatty pancreas Pancreatic fatty replacement Hyperglycaemia Hepatic stetosis Inflammageing Obesity Pdx1-Cre

URI

http://hdl.handle.net/10400.22/25532

Citation

Gaspar, T. B., Jesus, T. T., Azevedo, M. T., Macedo, S., Soares, M. A., Martins, R. S., Leite, R., Rodrigues, L., Rodrigues, D. F., Cardoso, L., Borges, I., Canberk, S., Gärtner, F., Miranda-Alves, L., Lopes, J. M., Soares, P., & Vinagre, J. (2023). Generation of an obese diabetic mouse model upon conditional Atrx Disruption. Cancers, 15(11), Artigo 11. https://doi.org/10.3390/cancers15113018