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Advisor(s)
Abstract(s)
Biomarkers from interstitial skin fluid (ISF) complement conventional biofluids for point-of-care testing and real-time monitoring. In this study, we propose a new approach that combines microneedle technology with molecularly imprinted polymers to improve transdermal electrochemical sensing. The molecularly imprinted polymer, which acts like a plastic antibody, is easy to synthesis and scalable, offering a low detection limit and rapid measurement (20 minutes). It detects IL -6, a proinflammatory cytokine associated with several clinical conditions, including neurological disease and pneumonia caused by SARS-CoV-2. The transdermal sensors successfully identified IL -6 in simulated skin ISF at very low concentrations (1 pg/mL). This breakthrough
enables affordable and bloodless testing, facilitating access to point-of-care testing worldwide. The integration of molecularly imprinted polymers and microneedle arrays is very promising for efficient transdermal electrochemical sensing that could find application in various clinical scenarios.
Description
Keywords
Microneedles; Interstitial skin fluid; Electrochemistry; Biosensor
Pedagogical Context
Citation
Oliveira, D., Correia, B.P., Sharma, S., & Moreira, F.T.C. (2023, September 11-15). Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing [Conference session]. NanoBio 2023 - 2nd International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece