Transdermal electrochemical sensing: Combining microneedles with  molecularly imprinted polymers for point-of-care testing

Oliveira, Daniela; Correia, Bárbara P.; Sharma, Sanjiv; Moreira, Felismina T.C.

Publication

Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing

2023Conference object

dc.contributor.author	Oliveira, Daniela
dc.contributor.author	Correia, Bárbara P.
dc.contributor.author	Sharma, Sanjiv
dc.contributor.author	Moreira, Felismina T.C.
dc.date.accessioned	2024-05-03T14:38:45Z
dc.date.available	2024-05-03T14:38:45Z
dc.date.issued	2023
dc.description.abstract	Biomarkers from interstitial skin fluid (ISF) complement conventional biofluids for point-of-care testing and real-time monitoring. In this study, we propose a new approach that combines microneedle technology with molecularly imprinted polymers to improve transdermal electrochemical sensing. The molecularly imprinted polymer, which acts like a plastic antibody, is easy to synthesis and scalable, offering a low detection limit and rapid measurement (20 minutes). It detects IL -6, a proinflammatory cytokine associated with several clinical conditions, including neurological disease and pneumonia caused by SARS-CoV-2. The transdermal sensors successfully identified IL -6 in simulated skin ISF at very low concentrations (1 pg/mL). This breakthrough enables affordable and bloodless testing, facilitating access to point-of-care testing worldwide. The integration of molecularly imprinted polymers and microneedle arrays is very promising for efficient transdermal electrochemical sensing that could find application in various clinical scenarios.	pt_PT
dc.description.version	N/A	pt_PT
dc.identifier.citation	Oliveira, D., Correia, B.P., Sharma, S., & Moreira, F.T.C. (2023, September 11-15). Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing [Conference session]. NanoBio 2023 - 2nd International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.22/25462
dc.language.iso	eng	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	pt_PT
dc.subject	Microneedles; Interstitial skin fluid; Electrochemistry; Biosensor	pt_PT
dc.title	Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing	pt_PT
dc.type	conference object
dspace.entity.type	Publication
oaire.awardURI	info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137832%2F2018/PT
oaire.citation.conferencePlace	Heraklion, Crete, Greece	pt_PT
oaire.citation.title	NanoBio 2023 - 2nd International Conference on Nanotechnologies and Bionanoscience, September 11-15	pt_PT
oaire.fundingStream	POR_NORTE
person.familyName	Sharma
person.familyName	Moreira
person.givenName	Sanjiv
person.givenName	Felismina
person.identifier	1589429
person.identifier.ciencia-id	C618-B958-12F5
person.identifier.ciencia-id	C917-6A46-A270
person.identifier.orcid	0000-0003-3828-737X
person.identifier.orcid	0000-0003-4237-8952
person.identifier.scopus-author-id	23486193000
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	closedAccess	pt_PT
rcaap.type	conferenceObject	pt_PT
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