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Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing

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dc.contributor.authorOliveira, Daniela
dc.contributor.authorCorreia, Bárbara P.
dc.contributor.authorSharma, Sanjiv
dc.contributor.authorMoreira, Felismina T.C.
dc.date.accessioned2024-05-03T14:38:45Z
dc.date.available2024-05-03T14:38:45Z
dc.date.issued2023
dc.description.abstractBiomarkers from interstitial skin fluid (ISF) complement conventional biofluids for point-of-care testing and real-time monitoring. In this study, we propose a new approach that combines microneedle technology with molecularly imprinted polymers to improve transdermal electrochemical sensing. The molecularly imprinted polymer, which acts like a plastic antibody, is easy to synthesis and scalable, offering a low detection limit and rapid measurement (20 minutes). It detects IL -6, a proinflammatory cytokine associated with several clinical conditions, including neurological disease and pneumonia caused by SARS-CoV-2. The transdermal sensors successfully identified IL -6 in simulated skin ISF at very low concentrations (1 pg/mL). This breakthrough enables affordable and bloodless testing, facilitating access to point-of-care testing worldwide. The integration of molecularly imprinted polymers and microneedle arrays is very promising for efficient transdermal electrochemical sensing that could find application in various clinical scenarios.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationOliveira, D., Correia, B.P., Sharma, S., & Moreira, F.T.C. (2023, September 11-15). Transdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testing [Conference session]. NanoBio 2023 - 2nd International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greecept_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/25462
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectMicroneedles; Interstitial skin fluid; Electrochemistry; Biosensorpt_PT
dc.titleTransdermal electrochemical sensing: Combining microneedles with molecularly imprinted polymers for point-of-care testingpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137832%2F2018/PT
oaire.citation.conferencePlaceHeraklion, Crete, Greecept_PT
oaire.citation.titleNanoBio 2023 - 2nd International Conference on Nanotechnologies and Bionanoscience, September 11-15pt_PT
oaire.fundingStreamPOR_NORTE
person.familyNameSharma
person.familyNameMoreira
person.givenNameSanjiv
person.givenNameFelismina
person.identifier1589429
person.identifier.ciencia-idC618-B958-12F5
person.identifier.ciencia-idC917-6A46-A270
person.identifier.orcid0000-0003-3828-737X
person.identifier.orcid0000-0003-4237-8952
person.identifier.scopus-author-id23486193000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication9c13153d-a73a-49ff-b7f6-c9733bc6725e
relation.isAuthorOfPublication.latestForDiscovery9c13153d-a73a-49ff-b7f6-c9733bc6725e
relation.isProjectOfPublicatione81c3669-d268-4f93-aa36-2c750e2a3675
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ISEP – CIETI – Comunicações em eventos científicos