Repository logo
 
Publication

Sleep disorders and genes

2019-03-29Book part Restricted access
Simple item page
dc.contributor.authorMurillo-Rodríguez, Eric
dc.contributor.authorYamamoto, Tetsuya
dc.contributor.authorVeras, André Barciela
dc.contributor.authorRocha, Nuno
dc.contributor.authorTelles-Correira, Diogo
dc.contributor.authorMachado, Sérgio
dc.contributor.authorMonteiro, Diogo
dc.contributor.authorBudde, Henning
dc.contributor.authorTorterolo, Pablo
dc.date.accessioned2023-06-12T10:35:21Z
dc.date.available2023-06-12T10:35:21Z
dc.date.issued2019-03-29
dc.description.abstractThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle. The sleep-wake cycle is under the control of diverse neuroanatomical and neurochemical systems, including monoaminergic, cholinergic, adenosinergic among many other systems. In addition, neuroanatomical centers linked to sleep promotion, such as hypothalamus, project to the cerebral cortex, subcortical relays and brainstem. In addition, the sleep-wake cycle has been associated to aberrant features known as sleep disorders. Here, we will discuss the role of specific gene expression on sleep disturbances. Given the expansion of the knowledge in the sleep-wake cycle area, it is indeed ambitious to describe all the genetics involved in the sleep modulation. However, in this chapter we reviewed the current understanding of the sleep disorders and gene expression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMurillo-Rodríguez, E., Yamamoto, T., Veras, A. B., Rocha, N. B., Telles-Correira, D., Machado, S., Monteiro, D., Budde, H., & Torterolo, P. (2019). Chapter 8—Sleep Disorders and Genes. Em E. Murillo-Rodríguez (Ed.), The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle (pp. 143–158). Academic Press. https://doi.org/10.1016/B978-0-12-816430-3.00008-7pt_PT
dc.identifier.doi10.1016/B978-0-12-816430-3.00008-7pt_PT
dc.identifier.isbn978-0-12-816430-3
dc.identifier.urihttp://hdl.handle.net/10400.22/23118
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B9780128164303000087?via%3Dihub#!pt_PT
dc.subjectCRISPR–Cas9pt_PT
dc.subjectGenept_PT
dc.subjectInsomniapt_PT
dc.subjectNarcolepsypt_PT
dc.subjectRestless legs syndromept_PT
dc.subjectSleep-wake cyclept_PT
dc.titleSleep disorders and genespt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage158pt_PT
oaire.citation.startPage143pt_PT
oaire.citation.titleThe Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cyclept_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
CAP_Nuno Rocha.pdf
Size:
279.42 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - TO - Livro, parte de livro ou capítulo de livro