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Orientador(es)
Resumo(s)
The sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle. The sleep-wake cycle is under the control of diverse neuroanatomical and neurochemical systems, including monoaminergic, cholinergic, adenosinergic among many other systems. In addition, neuroanatomical centers linked to sleep promotion, such as hypothalamus, project to the cerebral cortex, subcortical relays and brainstem. In addition, the sleep-wake cycle has been associated to aberrant features known as sleep disorders. Here, we will discuss the role of specific gene expression on sleep disturbances. Given the expansion of the knowledge in the sleep-wake cycle area, it is indeed ambitious to describe all the genetics involved in the sleep modulation. However, in this chapter we reviewed the current understanding of the sleep disorders and gene expression.
Descrição
Palavras-chave
CRISPR–Cas9 Gene Insomnia Narcolepsy Restless legs syndrome Sleep-wake cycle
Contexto Educativo
Citação
Murillo-Rodríguez, E., Yamamoto, T., Veras, A. B., Rocha, N. B., Telles-Correira, D., Machado, S., Monteiro, D., Budde, H., & Torterolo, P. (2019). Chapter 8—Sleep Disorders and Genes. Em E. Murillo-Rodríguez (Ed.), The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle (pp. 143–158). Academic Press. https://doi.org/10.1016/B978-0-12-816430-3.00008-7
Editora
Elsevier