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Electroanalytical determination of codeine in pharmaceutical preparations

2002Journal article Open access
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dc.contributor.authorGarrido, Jorge
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorBorges, Fernanda
dc.contributor.authorMacedo, Tice R. A.
dc.contributor.authorOliveira-Brett, A. M.
dc.date.accessioned2013-11-26T15:52:06Z
dc.date.available2013-11-26T15:52:06Z
dc.date.issued2002
dc.description.abstractA square wave voltammetric (SWV) method and a flow injection analysis systemwi th electrochemical detection (FIA-EC) using a glassy carbon electrode were evaluated for the determination of codeine in pharmaceutical preparations. The interference of several compounds, such as acetaminophen,guaiacol, parabens, ephedrine, acetylsalicylic acid and caffeine, that usually appear associated with codeine pharmaceutical preparations was studied. It was verified that these electroanalytical methods could not be used with acetaminophen present in the formulations and that with guaiacol, parabens or ephedrine present the use of the FIA-EC system was impracticable. A detection limit of 5 µmol L- 1 and a linear calibration range from 40 to 140 µmol L- 1 was obtained with the SWV method. For the flow injection analysis procedure a linear calibration range was obtained from 7 to 50 µmol L- 1 with a detection limit of 3 µmol L- 1 and the FIA-EC systemallowed a sampling rate of 115 samples per hour. The results obtained by the two methods, SWV and FIA-EC, were compared with those obtained using reference methods and demonstrated good agreement, with relative deviations lower than 4%.por
dc.identifier.doi10.1081/AL-120016539pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/2960
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor & Francispor
dc.relation.ispartofseriesAnalytical Letters; Vol. 35, Issue 15
dc.relation.publisherversionhttp://www.tandfonline.com/doi/abs/10.1081/AL-120016539#.UpSpk0r6Q25por
dc.subjectCodeinepor
dc.subjectSquare wave voltammetrypor
dc.subjectFlow injection analysis with electrochemical detectionpor
dc.subjectAcetaminophenpor
dc.subjectGuaiacolpor
dc.subjectParabenspor
dc.subjectEphedrinepor
dc.subjectAcetylsalicylic acidpor
dc.subjectCaffeinepor
dc.titleElectroanalytical determination of codeine in pharmaceutical preparationspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2498por
oaire.citation.startPage2487por
oaire.citation.titleAnalytical Letterspor
oaire.citation.volume35por
person.familyNameGarrido
person.familyNameDelerue-Matos
person.givenNameJorge
person.givenNameCristina
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0001-8981-231X
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id7202779733
person.identifier.scopus-author-id6603741848
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf548e711-c68e-4c49-9471-9923c047116d
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscoveryf548e711-c68e-4c49-9471-9923c047116d

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