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Advisor(s)
Abstract(s)
A square wave voltammetric (SWV) method and a flow injection
analysis systemwi th electrochemical detection (FIA-EC)
using a glassy carbon electrode were evaluated for the determination
of codeine in pharmaceutical preparations. The
interference of several compounds, such as acetaminophen,guaiacol, parabens, ephedrine, acetylsalicylic acid and
caffeine, that usually appear associated with codeine pharmaceutical
preparations was studied. It was verified that these
electroanalytical methods could not be used with acetaminophen
present in the formulations and that with guaiacol,
parabens or ephedrine present the use of the FIA-EC
system was impracticable. A detection limit of 5 µmol L- 1
and a linear calibration range from 40 to 140 µmol L- 1 was
obtained with the SWV method. For the flow injection
analysis procedure a linear calibration range was obtained
from 7 to 50 µmol L- 1 with a detection limit of 3 µmol L- 1
and the FIA-EC systemallowed a sampling rate of 115
samples per hour. The results obtained by the two methods,
SWV and FIA-EC, were compared with those obtained using
reference methods and demonstrated good agreement, with
relative deviations lower than 4%.
Description
Keywords
Codeine Square wave voltammetry Flow injection analysis with electrochemical detection Acetaminophen Guaiacol Parabens Ephedrine Acetylsalicylic acid Caffeine
Citation
Publisher
Taylor & Francis