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Advisor(s)
Abstract(s)
Diabetic ketoacidosis is a pathological condition characterized for the complex disordered metabolic state (as hyperglycemia, metabolic acidosis, dehydration or ketosis), caused by the total failing of insulin production for beta cells in the islets of Langerhans (type 1 diabetes) or abnormalities in the peripheral insulin action and insulin secretion (type 2 diabetes). This pathogenesis can be also associated with the increase of counter-regulation hormones, leading to an increase in the hepatic glucose synthesis and a decrease in the peripheral tissues, resulting in hyperglycemia and hyperosmolarity. The effect of lipolysis increase leads to an increase in the production of free fatty acids, which are oxidized in the hepatic microsomal system and converted to acetyl-CoA. When acetyl-CoA production exceeds hepatic utilization capacity, this substance acts as a substrate for the production of ketone bodies (β-hydroxybutyrate (BHB), acetoacetate and acetone), causing ketonemia and metabolic acidosis.
Description
Keywords
Diabetic ketoacidosis β-hydroxybutyrate Molecularly imprinted polymers Potentiometry
Citation
Martins, P. D. P., Truta, L. A. A. N. A., Fernandes, R., & Sales, M. G. F. (2019, abril). Artificial antibodies based potentiometric sensors for monitoring diabetic ketoacidosis [Comunicação oral]. Workshop on R&D projects: proceedings, Porto.